Abstract
The development of highly sensitive, cost-effective, miniature nanoparticle-based colorimetric nanoprobes attracted great attention in recent years. Depending on their excellent performance in environmental and biological analysis, colorimetric nanoprobes have been widely used for sensing a wide range of analytes/targets, such as metallic cations, anions, small organic molecules, oligonucleotides, proteins, cancer cells, etc. In this chapter, we first introduce the optical absorption properties of nanomaterial, mainly focusing on the noble metal nanomaterials, such as sphere gold nanoparticles, gold nanorods, and silver nanoparticles. Then we discuss the colorimetric sensing strategies for ions, small molecules, oligonucleotides, and protein detection and cellular analysis, highlighting some of their technical challenges and the new trends by means of a set of selected recent applications.
Keywords
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Kelly KL, Coronado E, Zhao LL, Schatz GC (2003) The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J Phys Chem B 107:668–677
Ray PC (2010) Size and shape dependent second order nonlinear optical properties of nanomaterials and their application in biological and chemical sensing. Chem Rev 110:5332–5365
Halas NJ, Lal S, Chang WS, Link S, Nordlander P (2011) Plasmons in strongly coupled metallic nanostructures. Chem Rev 111:3913–3961
Jain PK, Huang X, El-Sayed IH, El-Sayed MA (2008) Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. Acc Chem Res 41:1578–1586
Wang Z, Ma L (2009) Gold nanoparticle probes. Coord Chem Rev 253:1607–1618
Boisselier E, Astruc D (2009) Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38:1759–1782
Saha K, Agasti SS, Kim C, Li X, Rotello VM (2012) Gold nanoparticles in chemical and biological sensing. Chem Rev 112:2739–2779
Wilson R (2008) The use of gold nanoparticles in diagnostics and detection. Chem Soc Rev 37:2028–2045
Motl NE, Smith AF, DeSantisa CJ, Skrabalak SE (2014) Engineering plasmonic metal colloids through composition and structural design. Chem Soc Rev. doi:10.1039/C3CS60347D
Zhang JZ, Noguez C (2008) Plasmonic optical properties and applications of metal nanostructures. Plasmonics 3:127–150
Haes AJ, Haynes CL, McFarland AD, Schatz GC, Van Duyne RP, Zou S (2005) Plasmonic materials for surface-enhanced sensing and spectroscopy. MRS Bull 30:368–375
Jain PK, Lee KS, El-Sayed IH, El-Sayed MA (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110:7238–7248
Link S, El-Sayed MA (2003) Optical properties and ultrafast dynamics of metallic nanocrystals. Annu Rev Phys Chem 54:331–366
Griffin J, Singh AK, Senapati D, Lee E, Gaylor K, Jones-Boone J, Ray PC (2009) Sequence-specific HCV RNA quantification using the size-dependent nonlinear optical properties of gold nanoparticles. Small 5:839–845
Link S, El-Sayed MA (1999) Spectral properties and relaxation dynamics of surface plasmon electronic oscillations in gold and silver nanodots and nanorods. J Phys Chem B 103:8410–8426
Ye X, Jin L, Caglayan H, Chen J, Xing G, Zheng C, Doan-Nguyen V, Kang Y, Engheta N, Kagan CR (2012) Improved size-tunable synthesis of monodisperse gold nanorods through the use of aromatic additives. ACS Nano 6:2804–2817
Jakab A, Rosman C, Khalavka Y, Becker J, Trügler A, Hohenester U, Sönnichsen C (2011) Highly sensitive plasmonic silver nanorods. ACS Nano 5:6880–6885
Jones MR, Osberg KD, Macfarlane RJ, Langille MR, Mirkin CA (2011) Templated techniques for the synthesis and assembly of plasmonic nanostructures. Chem Rev 111:3736–3827
Murphy CJ, Thompson LB, Alkilany AM, Sisco PN, Boulos SP, Sivapalan ST, Yang JA, Chernak DJ, Huang J (2010) The many faces of gold nanorods. J Phys Chem Lett 1:2867–2875
Zeng J, Roberts S, Xia Y (2010) Nanocrystal-based time–temperature indicators. Chem Eur J 16:12559–12563
Singh AK, Senapati D, Neely A, Kolawole G, Hawker C, Ray PC (2009) Nonlinear optical properties of triangular silver nanomaterials. Chem Phys Lett 481:94–98
Becker J, Zins I, Jakab A, Khalavka Y, Schubert O, Sönnichsen C (2008) Plasmonic focusing reduces ensemble linewidth of silver-coated gold nanorods. Nano Lett 8:1719–1723
Xiang Y, Wu X, Liu D, Li Z, Chu W, Feng L, Zhang K, Zhou W, Xie S (2008) Gold nanorod-seeded growth of silver nanostructures: from homogeneous coating to anisotropic coating. Langmuir 24:3465–3470
Park G, Lee C, Seo D, Song H (2012) Full-color tuning of surface plasmon resonance by compositional variation of Au@Ag core-shell nanocubes with sulfides. Langmuir 28:9003–9009
Su K-H, Wei Q-H, Zhang X, Mock J, Smith DR, Schultz S (2003) Interparticle coupling effects on plasmon resonances of nanogold particles. Nano Lett 3:1087–1090
Daniel M-C, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104:293–346
Liu M, Guyot-Sionnest P (2004) Synthesis and optical characterization of Au/Ag core/shell nanorods. J Phys Chem B 108:5882–5888
Ma Y, Li W, Cho EC, Li Z, Yu T, Zeng J, Xie Z, Xia Y (2010) Au@ Ag core–shell nanocubes with finely tuned and well-controlled sizes, shell thicknesses, and optical properties. ACS Nano 4:6725–6734
Srivastava S, Frankamp BL, Rotello VM (2005) Controlled plasmon resonance of gold nanoparticles self-assembled with PAMAM dendrimers. Chem Mater 17:487–490
Chen L, Lou TT, Yu CW, Kang Q, Chen LX (2011) N-1-(2-mercaptoethyl)thymine modification of gold nanoparticles: a highly selective and sensitive colorimetric chemosensor for Hg2+. Analyst 136:4770–4773
Zhou Y, Wang S, Zhang K, Jiang X (2008) Visual detection of copper(II) by azide- and alkyne-functionalized gold nanoparticles using click chemistry. Angew Chem Int Ed 47:7454–7456
Cao R, Li B, Zhang Y, Zhang Z (2011) Naked-eye sensitive detection of nuclease activity using positively-charged gold nanoparticles as colorimetric probes. Chem Commun 47:12301–12303
Elghanian R, Storhoff JJ, Mucic RC, Letsinger RL, Mirkin CA (1997) Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. Science 277:1078–1081
Ai K, Liu Y, Lu L (2009) Hydrogen-bonding recognition-induced color change of gold nanoparticles for visual detection of melamine in raw milk and infant formula. J Am Chem Soc 131:9496–9497
Rosi NL, Mirkin CA (2005) Nanostructures in biodiagnostics. Chem Rev 105:1547–1562
Li D, Wieckowska A, Willner I (2008) Optical analysis of Hg2+ ions by oligonucleotide–gold-nanoparticle hybrids and DNA-based machines. Angew Chem Int Ed 120:3991–3995
Fu XL, Chen LX, Li JH, Lin M, You HY, Wang WH (2012) Label-free colorimetric sensor for ultrasensitive detection of heparin based on color quenching of gold nanorods by graphene oxide. Biosens Bioelectron 34:227–231
Lou TT, Chen ZP, Wang YQ, Chen LX (2011) Blue-to-red colorimetric sensing strategy for Hg(2+) and Ag(+) via redox-regulated surface chemistry of gold nanoparticles. ACS Appl Mater Interfaces 3:1568–1573
Chen Y-Y, Chang H-T, Shiang Y-C, Hung Y-L, Chiang C-K, Huang C-C (2009) Colorimetric assay for lead ions based on the leaching of gold nanoparticles. Anal Chem 81:9433–9439
Malile B, Chen JI (2013) Morphology-based plasmonic nanoparticle sensors: controlling etching kinetics with target-responsive permeability gate. J Am Chem Soc 135:16042–16045
Rex M, Hernandez FE, Campiglia AD (2006) Pushing the limits of mercury sensors with gold nanorods. Anal Chem 78:445–451
Lou TT, Chen LX, Chen ZP, Wang YQ, Chen L, Li JH (2011) Colorimetric detection of trace copper ions based on catalytic leaching of silver-coated gold nanoparticles. ACS Appl Mater Interfaces 3:4215–4220
Wang XK, Chen L, Chen LX (2013) Colorimetric determination of copper ions based on the catalytic leaching of silver from the shell of silver-coated gold nanorods. Microchim Acta 181:105–110
Wang GQ, Chen ZP, Chen LX (2011) Mesoporous silica-coated gold nanorods: towards sensitive colorimetric sensing of ascorbic acid via target-induced silver overcoating. Nanoscale 3:1756–1759
Xia Y, Ye J, Tan K, Wang J, Yang G (2013) Colorimetric visualization of glucose at the submicromole level in serum by a homogenous silver nanoprism-glucose oxidase system. Anal Chem 85:6241–6247
Lee JS, Han MS, Mirkin CA (2007) Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles. Angew Chem Int Ed 46:4093–4096
Huang CC, Chang HT (2007) Parameters for selective colorimetric sensing of mercury(II) in aqueous solutions using mercaptopropionic acid-modified gold nanoparticles. Chem Commun 12:1215–1217
Xue X, Wang F, Liu X (2008) One-step, room temperature, colorimetric detection of mercury (Hg2+) using DNA/nanoparticle conjugates. J Am Chem Soc 130:3244–3245
Yu CJ, Cheng TL, Tseng WL (2009) Effects of Mn2+ on oligonucleotide-gold nanoparticle hybrids for colorimetric sensing of Hg2+: improving colorimetric sensitivity and accelerating color change. Biosens Bioelectron 25:204–210
Xu Y, Deng L, Wang H, Ouyang X, Zheng J, Li J, Yang R (2011) Metal-induced aggregation of mononucleotides-stabilized gold nanoparticles: an efficient approach for simple and rapid colorimetric detection of Hg(II). Chem Commun 47:6039–6041
Lou T, Chen L, Zhang C, Kang Q, You H, Shen D, Chen L (2012) A simple and sensitive colorimetric method for detection of mercury ions based on anti-aggregation of gold nanoparticles. Anal Methods 4:488
Wang GL, Zhu XY, Jiao HJ, Dong YM, Li ZJ (2012) Ultrasensitive and dual functional colorimetric sensors for mercury (II) ions and hydrogen peroxide based on catalytic reduction property of silver nanoparticles. Biosens Bioelectron 31:337–342
Chen L, Fu XL, Lu WH, Chen LX (2013) Highly sensitive and selective colorimetric sensing of Hg2+ based on the morphology transition of silver nanoprisms. ACS Appl Mater Interfaces 5:284–290
Lin C-Y, Yu C-J, Lin Y-H, Tseng W-L (2010) Colorimetric sensing of silver (I) and mercury (II) ions based on an assembly of Tween 20-stabilized gold nanoparticles. Anal Chem 82:6830–6837
Guo Y, Wang Z, Qu W, Shao H, Jiang X (2011) Colorimetric detection of mercury, lead and copper ions simultaneously using protein-functionalized gold nanoparticles. Biosens Bioelectron 26:4064–4069
Wang Z, Lee JH, Lu Y (2008) Label-free colorimetric detection of lead ions with a nanomolar detection limit and tunable dynamic range by using gold nanoparticles and DNAzyme. Adv Mater 20:3263–3267
Chai F, Wang C, Wang T, Li L, Su Z (2010) Colorimetric detection of Pb2+ using glutathione functionalized gold nanoparticles. ACS Appl Mater Interfaces 2:1466–1470
Kalluri JR, Arbneshi T, Khan SA, Neely A, Candice P, Varisli B, Washington M, McAfee S, Robinson B, Banerjee S, Singh AK, Senapati D, Ray PC (2009) Use of gold nanoparticles in a simple colorimetric and ultrasensitive dynamic light scattering assay: selective detection of arsenic in groundwater. Angew Chem Int Ed 48:9668–9671
Xue Y, Zhao H, Wu Z, Li X, He Y, Yuan Z (2011) Colorimetric detection of Cd2+ using gold nanoparticles cofunctionalized with 6-mercaptonicotinic acid and L-cysteine. Analyst 136:3725–3730
Dang YQ, Li HW, Wang B, Li L, Wu Y (2009) Selective detection of trace Cr3+ in aqueous solution by using 5,5’-dithiobis (2-nitrobenzoic acid)-modified gold nanoparticles. ACS Appl Mater Interfaces 1:1533–1538
Li F-M, Liu J-M, Wang X-X, Lin L-P, Cai W-L, Lin X, Zeng Y-N, Li Z-M, Lin S-Q (2011) Non-aggregation based label free colorimetric sensor for the detection of Cr (VI) based on selective etching of gold nanorods. Sensor Actuators B Chem 155:817–822
Zhang Z, Zhang J, Lou T, Pan D, Chen L, Qu C, Chen Z (2012) Label-free colorimetric sensing of cobalt(II) based on inducing aggregation of thiosulfate stabilized gold nanoparticles in the presence of ethylenediamine. Analyst 137:400–405
Ma YR, Niu HY, Zhang XL, Cai YQ (2011) Colorimetric detection of copper ions in tap water during the synthesis of silver/dopamine nanoparticles. Chem Commun 47:12643–12645
Wang SS, Chen ZP, Chen L, Liu RL, Chen LX (2013) Label-free colorimetric sensing of copper(II) ions based on accelerating decomposition of H2O2 using gold nanorods as an indicator. Analyst 138:2080–2084
Chen ZP, Liu RL, Wang SS, Qu CL, Chen LX, Wang Z (2013) Colorimetric sensing of copper(ii) based on catalytic etching of gold nanorods. RSC Adv 3:13318
Hung YL, Hsiung TM, Chen YY, Huang CC (2010) A label-free colorimetric detection of lead ions by controlling the ligand shells of gold nanoparticles. Talanta 82:516–522
Lin S-Y, Liu S-W, Lin C-M, Chen C-H (2002) Recognition of potassium ion in water by 15-crown-5 functionalized gold nanoparticles. Anal Chem 74:330–335
Lin S-Y, Chen C-H, Lin M-C, Hsu H-F (2005) A cooperative effect of bifunctionalized nanoparticles on recognition: sensing alkali ions by crown and carboxylate moieties in aqueous media. Anal Chem 77:4821–4828
Kim S, Kim J, Lee NH, Jang HH, Han MS (2011) A colorimetric selective sensing probe for calcium ions with tunable dynamic ranges using cytidine triphosphate stabilized gold nanoparticles. Chem Commun 47:10299–10301
Eom MS, Jang W, Lee YS, Choi G, Kwon YU, Han MS (2012) A bi-ligand co-functionalized gold nanoparticles-based calcium ion probe and its application to the detection of calcium ions in serum. Chem Commun 48:5566–5568
Lisowski CE, Hutchison JE (2009) Malonamide-functionalized gold nanoparticles for selective, colorimetric sensing of trivalent lanthanide ions. Anal Chem 81:10246–10253
Daniel WL, Han MS, Lee J-S, Mirkin CA (2009) Colorimetric nitrite and nitrate detection with gold nanoparticle probes and kinetic end points. J Am Chem Soc 131:6362–6363
Xiao N, Yu C (2010) Rapid-response and highly sensitive noncross-linking colorimetric nitrite sensor using 4-aminothiophenol modified gold nanorods. Anal Chem 82:3659–3663
Chen ZP, Zhang ZY, Qu CL, Pan DW, Chen LX (2012) Highly sensitive label-free colorimetric sensing of nitrite based on etching of gold nanorods. Analyst 137:5197–5200
Tripathy SK, Woo JY, Han CS (2011) Highly selective colorimetric detection of hydrochloric acid using unlabeled gold nanoparticles and an oxidizing agent. Anal Chem 83:9206–9212
Chen L, Lu WH, Wang XK, Chen LX (2013) A highly selective and sensitive colorimetric sensor for iodide detection based on anti-aggregation of gold nanoparticles. Sensor Actuators B Chem 182:482–488
Zhang ZY, Zhang J, Qu CL, Pan DW, Chen ZP, Chen LX (2012) Label free colorimetric sensing of thiocyanate based on inducing aggregation of Tween 20-stabilized gold nanoparticles. Analyst 137:2682–2686
Jiang Y, Zhao H, Zhu N, Lin Y, Yu P, Mao LQ (2008) A simple assay for direct colorimetric visualization of trinitrotoluene at picomolar levels using gold nanoparticles. Angew Chem Int Ed 47:8601–8604
Dasary SS, Senapati D, Singh AK, Anjaneyulu Y, Yu H, Ray PC (2010) Highly sensitive and selective dynamic light-scattering assay for TNT detection using p-ATP attached gold nanoparticle. ACS Appl Mater Interfaces 2:3455–3460
Radhakumary C, Sreenivasan K (2011) Naked eye detection of glucose in urine using glucose oxidase immobilized gold nanoparticles. Anal Chem 83:2829–2833
Kong B, Zhu A, Luo Y, Tian Y, Yu Y, Shi G (2011) Sensitive and selective colorimetric visualization of cerebral dopamine based on double molecular recognition. Angew Chem Int Ed 50:1837–1840
Feng JJ, Guo H, Li YF, Wang YH, Chen WY, Wang AJ (2013) Single molecular functionalized gold nanoparticles for hydrogen-bonding recognition and colorimetric detection of dopamine with high sensitivity and selectivity. ACS Appl Mater Interfaces 5:1226–1231
Guo L, Zhong J, Wu J, Fu F, Chen G, Zheng X, Lin S (2010) Visual detection of melamine in milk products by label-free gold nanoparticles. Talanta 82:1654–1658
Zhang Y, Li B, Xu C (2010) Visual detection of ascorbic acid via alkyne-azide click reaction using gold nanoparticles as a colorimetric probe. Analyst 135:1579–1584
Wang J, Wang L, Liu X, Liang Z, Song S, Li W, Li G, Fan C (2007) A gold nanoparticle-based aptamer target binding readout for ATP assay. Adv Mater 19:3943–3946
Liu J, Lu Y (2004) Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor. Anal Chem 76:1627–1632
Liu J, Lu Y (2005) Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. Angew Chem Int Ed 45:90–94
Zhang J, Wang L, Pan D, Song S, Boey FY, Zhang H, Fan C (2008) Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. Small 4:1196–1200
Sun J, Ge J, Liu W, Fan Z, Zhang H, Wang P (2011) Highly sensitive and selective colorimetric visualization of streptomycin in raw milk using Au nanoparticles supramolecular assembly. Chem Commun 47:9888–9890
Zhang X, Zhao H, Xue Y, Wu Z, Zhang Y, He Y, Li X, Yuan Z (2012) Colorimetric sensing of clenbuterol using gold nanoparticles in the presence of melamine. Biosens Bioelectron 34:112–117
Kim YS, Kim JH, Kim IA, Lee SJ, Jurng J, Gu MB (2010) A novel colorimetric aptasensor using gold nanoparticle for a highly sensitive and specific detection of oxytetracycline. Biosens Bioelectron 26:1644–1649
Sun J, Guo L, Bao Y, Xie J (2011) A simple, label-free AuNPs-based colorimetric ultrasensitive detection of nerve agents and highly toxic organophosphate pesticide. Biosens Bioelectron 28:152–157
Zhang M, Liu YQ, Ye BC (2011) Rapid and sensitive colorimetric visualization of phthalates using UTP-modified gold nanoparticles cross-linked by copper(II). Chem Commun 47:11849–11851
Li L, Li B (2009) Sensitive and selective detection of cysteine using gold nanoparticles as colorimetric probes. Analyst 134:1361–1365
Sudeep P, Joseph SS, Thomas KG (2005) Selective detection of cysteine and glutathione using gold nanorods. J Am Chem Soc 127:6516–6517
Zhang M, Ye BC (2011) Colorimetric chiral recognition of enantiomers using the nucleotide-capped silver nanoparticles. Anal Chem 83:1504–1509
Tan YN, Lee KH, Su X (2011) Study of single-stranded DNA binding protein-nucleic acids interactions using unmodified gold nanoparticles and its application for detection of single nucleotide polymorphisms. Anal Chem 83:4251–4257
Zu Y, Ting AL, Yi G, Gao Z (2011) Sequence-selective recognition of nucleic acids under extremely low salt conditions using nanoparticle probes. Anal Chem 83:4090–4094
Wei H, Li B, Li J, Wang E, Dong S (2007) Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes. Chem Commun 36:3735–3737
Zhen Z, Tang LJ, Long H, Jiang JH (2012) Enzymatic immuno-assembly of gold nanoparticles for visualized activity screening of histone-modifying enzymes. Anal Chem 84:3614–3620
Huang C-C, Huang Y-F, Cao Z, Tan W, Chang H-T (2005) Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors. Anal Chem 77:5735–5741
Xue W, Zhang G, Zhang D (2011) A sensitive colorimetric label-free assay for trypsin and inhibitor screening with gold nanoparticles. Analyst 136:3136–3141
Liu D, Chen W, Tian Y, He S, Zheng W, Sun J, Wang Z, Jiang X (2012) A highly sensitive gold-nanoparticle-based assay for acetylcholinesterase in cerebrospinal fluid of transgenic mice with Alzheimer’s disease. Adv Healthc Mater 1:90–95
Wu Z, Wu ZK, Tang H, Tang LJ, Jiang JH (2013) Activity-based DNA-gold nanoparticle probe as colorimetric biosensor for DNA methyltransferase/glycosylase assay. Anal Chem 85:4376–4383
Medley CD, Smith JE, Tang Z, Wu Y, Bamrungsap S, Tan W (2008) Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal Chem 80:1067–1072
Lu W, Arumugam SR, Senapati D, Singh AK, Arbneshi T, Khan SA, Yu H, Ray PC (2010) Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano 4:1739–1749
Kim Y, Johnson RC, Hupp JT (2001) Gold nanoparticle-based sensing of “spectroscopically silen” heavy metal ions. Nano Lett 1:165–167
Beqa L, Singh AK, Khan SA, Senapati D, Arumugam SR, Ray PC (2011) Gold nanoparticle-based simple colorimetric and ultrasensitive dynamic light scattering assay for the selective detection of Pb(II) from paints, plastics, and water samples. ACS Appl Mater Interfaces 3:668–673
Wei H, Li B, Li J, Dong S, Wang E (2008) DNAzyme-based colorimetric sensing of lead (Pb(2+)) using unmodified gold nanoparticle probes. Nanotechnology 19:095501
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Chen, L., Wang, Y., Fu, X., Chen, L. (2014). Colorimetric Nanoprobes. In: Novel Optical Nanoprobes for Chemical and Biological Analysis. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43624-0_2
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DOI: https://doi.org/10.1007/978-3-662-43624-0_2
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