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Children’s Oncology Group (COG) Trials for Retinoblastoma

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Clinical Ophthalmic Oncology

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Abstract

For the past 30 years, retinoblastoma, a tumor that occurs in only 3 % of children with cancer, has been the subject of extensive molecular biologic research. However, apart from a short period in the 1970s, retinoblastoma has not been studied by any of the pediatric cooperative groups. The past decade has witnessed significant multidisciplinary prospective clinical and biologic studies of this rare pediatric neoplasm. The Children’s Oncology Group (COG) has successfully opened four clinical trials with a fifth recently approved. This chapter will review these ongoing prospective multicenter trials.

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Author information

Authors and Affiliations

  1. The Retinoblastoma Center of Houston, MD Anderson Cancer Center/Texas Children’s Hospital, Baylor College of Medicine/Methodist Hospital Research Institute, 1515 Holcombe Boulevard Unit 1445, Houston, TX, 77030, USA

    Dan S. Gombos MD, FACS

  2. The Children’s Hospital of Philadelphia, 34th & Civic Center Blvd., Philadelphia, PA, 19104, USA

    Anna T. Meadows MD

  3. Texas Children’s Cancer Center at Baylor College, 6621 Fannin Street, Mc3-3320, Houston, TX, 77030-2399, USA

    Murali Chintagumpala MD

  4. Memorial Sloan Kettering Cancer Center, 1275 York Ave., 185, New York, NY, 10021, USA

    Ira J. Dunkel MD

  5. Division of Hematology-Oncology, Vanderbilt University School of MediciNE, 2220 Pierce Ave 397 PRB, Nashville, TN, 37232-6310, USA

    Debra Friedman MD

  6. University of Nebraska Medical Center, 984350 Nebraska Medical Center, Omaha, NE, 68198-4350, USA

    Julie Ann Stoner PhD

  7. Children’s Hospital of Los Angeles, 4650 Sunset Boulevard, MS 54, Los Angeles, CA, 90027, USA

    Rima Jubran MD & Judith Grob Villablanca MD

Authors
  1. Dan S. Gombos MD, FACS
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  2. Anna T. Meadows MD
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  3. Murali Chintagumpala MD
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  4. Ira J. Dunkel MD
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  5. Debra Friedman MD
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  6. Julie Ann Stoner PhD
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  7. Rima Jubran MD
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  8. Judith Grob Villablanca MD
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Corresponding author

Correspondence to Dan S. Gombos MD, FACS .

Editor information

Editors and Affiliations

  1. Dept. of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

  2. Department of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, USA

    A. Linn Murphree

  3. University of California, San Francisco, California, USA

    Bertil E. Damato

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© 2015 Springer-Verlag Berlin Heidelberg

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Gombos, D.S. et al. (2015). Children’s Oncology Group (COG) Trials for Retinoblastoma. In: Singh, A., Murphree, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43451-2_21

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  • DOI: https://doi.org/10.1007/978-3-662-43451-2_21

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43450-5

  • Online ISBN: 978-3-662-43451-2

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