Children’s Oncology Group (COG) Trials for Retinoblastoma

  • Dan S. GombosEmail author
  • Anna T. Meadows
  • Murali Chintagumpala
  • Ira J. Dunkel
  • Debra Friedman
  • Julie Ann Stoner
  • Rima Jubran
  • Judith Grob Villablanca


For the past 30 years, retinoblastoma, a tumor that occurs in only 3 % of children with cancer, has been the subject of extensive molecular biologic research. However, apart from a short period in the 1970s, retinoblastoma has not been studied by any of the pediatric cooperative groups. The past decade has witnessed significant multidisciplinary prospective clinical and biologic studies of this rare pediatric neoplasm. The Children’s Oncology Group (COG) has successfully opened four clinical trials with a fifth recently approved. This chapter will review these ongoing prospective multicenter trials.


Stem Cell Rescue Bone Marrow Disease Optic Nerve Involvement Bilateral Retinoblastoma Intraocular Retinoblastoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Dan S. Gombos
    • 1
    Email author
  • Anna T. Meadows
    • 2
  • Murali Chintagumpala
    • 3
  • Ira J. Dunkel
    • 4
  • Debra Friedman
    • 5
  • Julie Ann Stoner
    • 6
  • Rima Jubran
    • 7
  • Judith Grob Villablanca
    • 7
  1. 1.The Retinoblastoma Center of Houston, MD Anderson Cancer Center/Texas Children’s Hospital, Baylor College of Medicine/Methodist Hospital Research InstituteHoustonUSA
  2. 2.The Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  3. 3.Texas Children’s Cancer Center at Baylor CollegeHoustonUSA
  4. 4.Memorial Sloan Kettering Cancer CenterNew YorkUSA
  5. 5.Division of Hematology-OncologyVanderbilt University School of MediciNENashvilleUSA
  6. 6.University of Nebraska Medical CenterOmahaUSA
  7. 7.Children’s Hospital of Los AngelesLos AngelesUSA

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