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Photoswitchable Ion Channels and Receptors

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Novel Approaches for Single Molecule Activation and Detection

Part of the book series: Advances in Atom and Single Molecule Machines ((AASMM))

Abstract

The development of photochromic and photoswitchable ligands for ion channels and receptors has made important contributions to optopharmacology and optogenetic pharmacology. These compounds provide new tools to study ion channel proteins and to understand their function and pathological implications. Here, we describe the design, operation, and applications of the available photoswitches, with special emphasis on ligand- and voltage-gated channels.

Antoni Bautista-Barrufet and Mercè Izquierdo-Serra contributed equally to this work

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Author information

Authors and Affiliations

  1. Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain

    Antoni Bautista-Barrufet, Mercè Izquierdo-Serra & Pau Gorostiza

  2. Institut Català d’Investigació Química (ICIQ), Tarragona, Spain

    Antoni Bautista-Barrufet

  3. Centro de Investigación Biomédica en Red en Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain

    Pau Gorostiza

  4. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    Pau Gorostiza

Authors
  1. Antoni Bautista-Barrufet
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  2. Mercè Izquierdo-Serra
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  3. Pau Gorostiza
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Corresponding author

Correspondence to Pau Gorostiza .

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Editors and Affiliations

  1. Department of Neuroscience and Neurotechnology, University of Genoa The Italian Institute of Technology, Genoa, Italy

    Fabio Benfenati

  2. Nanostructures Department, The Italian Institute of Technology, Genoa, Italy

    Enzo Di Fabrizio

  3. Neuroscience Area, Scuola Internazionale Superiore di Studi, Trieste, Italy

    Vincent Torre

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Bautista-Barrufet, A., Izquierdo-Serra, M., Gorostiza, P. (2014). Photoswitchable Ion Channels and Receptors. In: Benfenati, F., Di Fabrizio, E., Torre, V. (eds) Novel Approaches for Single Molecule Activation and Detection. Advances in Atom and Single Molecule Machines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43367-6_9

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