Skip to main content
SpringerLink
Log in

Die Gruppe der Myxoviren. Ihre Untersuchung mittels fluorescierender Antikörper

  • Conference paper
Ergebnisse der Mikrobiologie Immunitätsforschung und Experimentellen Therapie

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 35))

Zusammenfassung

Auf Grund der Vorschläge von Andrewes, Bang und Burnet (1955) werden in dieser Gruppe folgende Virusarten zusammengefaßt: Influenzavirus A, B, C (M. influenzae A, B, C), Newcastle Disease-Virus (M. multiforme), Geflügelpest-virus (M. pestis galli), Mumpsvirus (M. parotidis). Ebenfalls zu dieser Gruppe rechnet man nach Andrewes, Bang, Chanock und Zhdanow (1959) die Parainfluenzaviren (M. para-influenzae 1-3). Die allen Species gemeinsame Eigenschaft, mit der auch die Aufstellung dieser Gruppe motiviert wurde, beruht auf ihrem Verhalten gegenüber Erythrocyten. Die Viruspartikel lagern sich an die Oberfläche von Blutkörperchen verschiedener Tierspecies an und bewirken dadurch eine Hämagglutination (Hurst 1941). Diese Adsorption wird von einer mehr oder weniger vollständigen Elution gefolgt, wobei in einem enzymatischen Prozeß die mucoproteinhaltigen Receptoren der Erythrocytenoberfläche irreversibel zerstört werden. Die Adsorption von Viren kann durch im Serum vorkommende Mucoproteine verhindert werden; Erythrocyten, die mit dem Receptor-destroyingEnzyme von Vibrio cholerae behandelt wurden, lassen sich durch Viren nicht mehr agglutinieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ada, G. L.: Ribonucleic acid in influenza virus. Ciba Foundation Symp.: Nature of viruses, p. 104. London: Churchill 1957.

    Google Scholar 

  • Andrewes, C. H.: Virus Iii in tissue culture. I. The appearance of intranuclear inclusions in vitro. Brit. J. exp. Path. 10, 188 (1929a).

    Google Scholar 

  • Andrewes, C. H.: Virus Iii in tissue culture. II. Further observations on the formation of inclusions bodies. Iii. Experiments bearing on immunity. Brit. J. exp. Path. 10, 273 (1929b).

    Google Scholar 

  • Andrewes, C. H.: Tissue-culture in the study of immunity in herpes. J. Path. Bact. 33, 301 (1930).

    Article  Google Scholar 

  • Andrews, C. H., F. B. Bang and F. M. Burnet: A short description of the myxovirus group (influenza and related viruses). Virology 1, 176 (1955).

    Article  Google Scholar 

  • Andrewes, C. H., F. B. Bang, R. M. Chanock and V. M. Zhdanow: Para-influenza virus 1, 2 and 3. Suggested names of recently described myxoviruses. Virology 8, 129 (1959).

    CAS  Google Scholar 

  • Bang, F. B.: The development of Ndv in cells of the chorioallantoic membrane as studied by thin sections. Bull. Johns Hopk. Hosp. 92, 309 (1953).

    CAS  Google Scholar 

  • Bang, F. B. and A. Isaacs: Morphological aspects of virus cell relationships in influenza, mumps and Newcastle. Ciba Foundation Symp.: The nature of viruses, p. 249. London: Churchill 1957.

    Google Scholar 

  • Beutner, E. H.: Immunofluorescent staining: The fluorescent antibody method. Bact. Rev. 25, 49 (1961).

    PubMed  CAS  Google Scholar 

  • Birch-Andersen, A., and K. Paucker: Studies on the structure of influenza virus. II. Ultrathin sections of infectious and non-infectious particles. Virology 8, 21 (1959).

    Article  Google Scholar 

  • Boand. A. V., J. E. Kempf and R. J. Hanson: Phagocytosis of influenza virus. I. In vitro observations. J. Immunol. 79, 416 (1957).

    Google Scholar 

  • Breitenfeld, P. M., and W. SchÄFer: The formation of fowl plague antigens in infected cells, as studied with fluorescent antibodies. Virology 4, 328 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Burnstein, T., and F. B. Bang: Infection of the upper respiratory tract of the chick with a mild (vaccine) strain of Newcastle Disease virus. Bull. Johns Hopk. Hosp. 102, 127 (1958).

    CAS  Google Scholar 

  • Chadwick, C. S., M. G. Mcentegart and R. C. Nairn: Fluorescent protein tracers. A trial of new fluorochroms and the development of an alternative to fluorescein. Immunology 1, 315 (1958).

    PubMed  CAS  Google Scholar 

  • Chadwick, C. S., M. G. Mcentegart and R. C. Nairn: Fluorescent protein tracers. A simple alternative to fluorescein. Lancet 1958, 412.

    Google Scholar 

  • Chu, T. H., F. S. Cheever, A. H. Coons and J. B. Daniels: Distribution of mumps virus in the experimentally infected monkey. Proc. Soc. Biol. 76, 571 (1951).

    Article  CAS  Google Scholar 

  • Coons, A. H.: Histochemistry with labelled antibody. Int. Rev. Cytol. 5, 1 (1956).

    Article  CAS  Google Scholar 

  • Coons, A. H.: The morphological aspects of virus infections of cells as revealed by fluorescent antibody. Ciba Foundation Symp.: The nature of viruses, p. 203. London: Churchill 1957.

    Google Scholar 

  • Coons, A. H.: Fluorescent antibody methods. General cytochemical methods, vol. 1, p. 399. New York: Academic Press 1958.

    Google Scholar 

  • Coons, A. H.: Antibodies and antigens labelled with fluorescein. Schweiz. Z. Path. 22, 693 (1959 a).

    Google Scholar 

  • Coons, A. H.: The diagnostic application of fluorescent antibodies. Schweiz. Z. Path. 22, 700 (1959 b). The beginnings of immunofluorescence. J. Immunol. 87, 499 (1961).

    CAS  Google Scholar 

  • Fraser, K. B., R. C. Nairn, M. G. Mcentegart and C. S. Chadwick: Neurotropic influenza A infection of mouse brain studied with fluorescent antibody. J. Path. Bact. 78, 423 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Frisch-Niggemeyer, W.: Über die chemische Zusammensetzung und die innere Struktur des Influenzavirus unter besonderer Berücksichtigung des sog. „löslichen Antigens“. Zbl. Bakt., I. Abt. Orig. 183, 294 (1961).

    Google Scholar 

  • Furusawa, E., E. Baba, K. Toyoshima and J. Kamahora: The effect of antibody on intracellular virus multiplication. II. Med. J. Osaka Univ. 7, 701 (1957).

    Google Scholar 

  • Furusawa, E., K. Hagiwara and J. Kamahora: The effect of antibody on intracellular virus multiplication. I. Med. J. Osaka Univ. 7, 551 (1956).

    Google Scholar 

  • Goldwasser, R. A., and C. C. Shepard: Staining of complement and modification of fluorescent antibody procedures. J. Immunol. 80, 122 (1958).

    PubMed  CAS  Google Scholar 

  • Gottschalk, A.: Chemistry of virus receptors. Burnet and Stanley: The viruses, vol. 3, p. 51. London: Academic Press 1959.

    Google Scholar 

  • Haagen, E.: Weitere Untersuchungen über das Verhalten des Gelbfiebervirus in der Gewebskultur. Zbl. Bakt., I. Abt. Orig. 128, 13 (1933 a).

    Google Scholar 

  • Haagen, E.: Über die Notwendigkeit lebender Zellen zur Viruszüchtung. Weitere Untersuchungen über das Gelbfieber-, Variola-, Vakzine-und Herpesvirus. Zbl. Bakt., I. Abt. Orig. 129, 237 (1933b).

    Google Scholar 

  • Hallauer, C: Immunitätsstudien bei Hühnerpest. Z. Hyg. Infekt.-Kr. 116, 456 (1934).

    Article  Google Scholar 

  • Hanson, R. J., J. E. Kempf and A. V. Boand jr.: Phagocytosis of influenza virus. II. Its occurence in normal and immune mice. J. Immunol. 79, 422 (1957).

    PubMed  CAS  Google Scholar 

  • Henle, G., A. Girardi and W. Henle: A non-transmissible cytopathogenic effect of influenza virus in tissue culture accompanied by formation of non-infectious hemagglutinins. J. exp. Med. 101, 25 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Henle, W.: Persönliche Mitteilung 1960.

    Google Scholar 

  • Henle, W.: Influenzavirus im Wandel der Zeit. Zbl. Bakt. I. Abt. 184, 36 (1962).

    CAS  Google Scholar 

  • Henle, W. and G. Henle: Studies on host-virus interactions in the chick embryo-influenza virus system. Iii. Development of infectivity, hemagglutination and complement fixation activities during the first infectious cycle. J. exp. Med. 90, 23 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Henle, W. and K. Paucker: Interference between inactivated and active influenza viruses in the chick embryo. I. A re-evaluation of factors of dosage and timing using infectivity titrations for assay. Virology 6, 181 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Henle, W. and M. Wiener: Complement fixation antigens of influenza viruses type A and B. Proc. Soc. exp. Biol. (N.Y.) 57, 176 (1944).

    CAS  Google Scholar 

  • Hillls, W. D., M. A. J. Moffat and O. A. Holtermann: The development of soluble and viral antigens of influenza A virus in tissue culture as studied by the fluorescent antibody technique. 3. Studied on the abortive cycle of replication in HeLa cells. Acta path. microbiol. scand. 50, 419 (1960).

    Article  Google Scholar 

  • Hirst, G. K.: The agglutination of red cells by allantoicfluid of chick embryo infected with influenza virus. Science 94, 22 (1941).

    Article  PubMed  CAS  Google Scholar 

  • Holtermann, O. A., W. D. Hillis and M. A. J. Moffat: The development of soluble and viral antigens of influenza A virus in tissue culture as studied by the fluorescent antibody technique. I. Studies employing a low multiplicity of infection in beef embryo kidney cells. Acta path. microbiol. scand. 50, 398 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Horne, R. W., A. P. Waterson, P. Wildy and A. E. Farnham • The structure and composition of the myxoviruses. 1. Electron microscope studies of the structure of myxovirus particles by negative staining techniques. Virology 11, 79 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Horne, R. W., and P. Wildy: Symmetry in virus architecture. Virology 15, 348 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Hozz, G., and W. SchÄFer: Ultrahistologische Studie über die Vermehrung des Virus der klassischen Geflügelpest. Z. Naturforsch. 10b, 1 (1955).

    Google Scholar 

  • Hoyle, L., and R. W. Fairbrother: Antigenic structure of influenza viruses; preparation of elementary body suspensions and nature of complement-fixing antigens. J. Hyg. (Loud.) 37, 512 (1937).

    Article  CAS  Google Scholar 

  • Hoyle, L., R. W. Horne and A. P. Waterson: The structure and composition of the myxoviruses. II. Components released from the influenza virus particle by ether. Virology 13, 448 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Johnson, C. D., and E. W. Goodpasture: The histopathology of experimental mumps in the monkey, macacus rhesus. Amer. J. Path. 12, 495 (1936).

    PubMed  CAS  Google Scholar 

  • Kirber, M. W., and W. Henle: A comparison of influenza complement fixation antigens derived from allantoic fluids and membranes. J. Immunol. 65, 229 (1950).

    PubMed  CAS  Google Scholar 

  • Klein, P., u. P. Burkholder: Die Darstellung von fixiertem Komplement mit markiertem Antikomplement. Schweiz. Z. Path. 22, 729 (1959).

    CAS  Google Scholar 

  • Lewis, W. H.: Pinocytosis. Bull. Johns Hopk. Hosp. 49, 17 (1931).

    Google Scholar 

  • Liu, C.: Studies on influenza in ferrets by means of fluorescein labelled antibody. I. The pathogenesis and diagnosis of the disease. J. exp. Med. 101, 665 (1952).

    Google Scholar 

  • Liu, C.: Studies on influenza infections in ferrets by means of fluorescein labelled antibody. II. The role of „soluble antigen“ in nuclear fluorescence and crossreactions. J. exp. Med. 101, 677 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Liu, C.: Rapid diagnosis of human influenza infection from nasal smears by means of fluorescein labelled antibody. Proc. Soc. exp. Biol. (N.Y.) 92, 883 (1956).

    Article  CAS  Google Scholar 

  • Liu, C. and M. D. Eaton: Study and isolation of primary atypical pneumonia virus in chick embryos by means of fluorescein labelled antibody. Bact. Proc. 61 (1955).

    Google Scholar 

  • LÖFfler, H.: Unveröffentlichte Versuche 1959.

    Google Scholar 

  • LÖFfler, H.: Der inkomplette Infektionszyklus von Influenza-Virus in HeLa-Zellen. Fluoreszenz-mikroskopische Untersuchungen. Path. Microbiol. 24, 988 (1961).

    Google Scholar 

  • LÖFfler, H.: G. Henle and W. Henle: Attempts to influence the incomplete reproductive cycle of influenza virus in HeLa cells by antibodies. J. Immunol. (im Druck).

    Google Scholar 

  • Lwoff, A.: Diskussionsbeitrag. Ciba Foundation Symp. The nature of viruses, p. 121. London: Churchill 1957.

    Google Scholar 

  • Magill, T. P., and T. Francis jr.: The action of immune serum on human influenza virus in vitro. J. exp. Med. 65, 861 (1937).

    Article  PubMed  CAS  Google Scholar 

  • Magnus, P. V.: Studies on interference in experimental influenza. Ark. Kemi, Mineral. Geol. 24B, No 7 (1946).

    Google Scholar 

  • Magnus, P. V.: Propagation of the PR8-strain of influenza virus in chick embryo. II. The formation of „incomplete“ virus following inoculation of large doses of seed virus. Acta path. microbiol. scand. 28, 250 (1951).

    Article  Google Scholar 

  • Martin, C. M., C. M. Kunin, L. S. Gottlieb, M. W. Bernes, C. LIu and M. Finland: Asian influenza A in Boston 1957–1958. I. Observation on thirty-two influenza associated fatal cases. Arch. intern. Med. 103, 515 (1959).

    CAS  Google Scholar 

  • Moffat, M. A. J., O. A. Holtermann and W. D. Hillis: The development of soluble and viral antigens of influenza A virus in tissue culture as studied by the fluorescent antibody technique. 2. Studies employing a high multiplicity of infection in beef embryo kidney cells. Acta path. microbiol. scand. 50, 409 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Muller, F., u. D. Klein: Fluoreszenz-serologische Darstellung der Komplementbindung an Virus-Antikörper-Komplexen in der Gewebekultur. Dtsch. med. Wschr. 84, 2195 (1959).

    Google Scholar 

  • Murphy, J. S., and F. B. Bang: Observations with the electron microscope on cells of the chick chorio-allantoic membrane infected with influenza virus. J. exp. Med. 95, 259 (1952).

    Article  PubMed  CAS  Google Scholar 

  • O’Dea, J. F., and J. K. Dineen: Fluorescent antibody studies with herpes simplex virus in unfixed preparation of trypsinized tissue cultures. J. gen. Microbiol. 17, 19 (1957).

    Article  Google Scholar 

  • Paucker, K., A. Birch-Andersen and P. v. Magnus: Studies on the structure of influenza virus. I. Components of infectious and incomplete particles. Virology 8, 1 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Paucker, K. and W. Henle: Interference between inactivated and active influenza viruses in the chick embryo. II. Interference by incomplete forms of influenza virus. Virology 6, 198 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Prince, A. M., and H. A. Ginsberg: Immunohistochemical studies on the interaction between Ehrlich ascites tumor cells and Newcastle disease virus. J. exp. Med. 105, 177 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Puck, T.: Quantitative measurement of virus action by cell plating techniques. Perspectives in Virology, p. 88. New York: John Wiley 1959.

    Google Scholar 

  • Riggs, J. L., R. J. Seiwald, J. H. Burckhalter, C. M. Downs and T. G. Metcalf: Isothiocyanate compounds as fluorescent labeling agents for immune serum. Amer. J. Path. 34, 1081 (1958).

    PubMed  CAS  Google Scholar 

  • Rivers, T. M., E. Haagen and R. S. Muckenfuss: Development in tissue cultures of the intracellular changes characteristic of vaccinal and herpetic infections. J. exp. Med. 50, 665 (1929a).

    Article  PubMed  CAS  Google Scholar 

  • Rivers, T. M., E. Haagen and R. S. Muckenfuss: A study of vaccinal immunity in tissue cultures. J. exp. Med. 50, 673 (1929 b).

    Google Scholar 

  • Rous, P., P. D. Mcmaster and S. S. Hudacx: The fixation and protection of viruses by the cells of susceptible animals J exp. Med. 61, 657 (1935).

    Article  PubMed  CAS  Google Scholar 

  • Rott, R., and W. SchÄFer: Finestructure of subunits isolated from Newcastle disease Virus. Virology 14, 298 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Sabin, A. B.: The mechanism of immunity to filtrable viruses. II. Fate of the virus in a system consisting of susceptible tissue, immune serum and virus, and the sole of the tissue in the mechanism of immunity. Brit. J. exp. Path. 16, 84 (1935).

    CAS  Google Scholar 

  • SchÄFer, W.: Units isolated after splitting fowl plague virus. Ciba Foundation Symp.: The nature of viruses, p. 91. London: Churchill 1957.

    Google Scholar 

  • SchÄFer, W. and R. Rott: Untereinheiten von Newcastle Disease-und Mumps-Virus. Z. Naturforsch. 14b, 629 (1959).

    Google Scholar 

  • SchÄFer, W. u W. ZilllG: Über den Aufbau des Viruselementarteilchens der klassischen Gefliigelpest. Z. Naturforsch. 96, 779 (1954).

    Google Scholar 

  • Schlesinger, R. W.: Incomplete growth cycle of influenza virus in mouse brain. Proc. Soc. exp. Biol. (N.Y.) 74, 541 (1950).

    Article  CAS  Google Scholar 

  • Silverstein, A. M.: Contrasting fluorescent labels for two antibodies. J. Histochem. Cytochem. 5, 94 (1957).

    Article  Google Scholar 

  • Smith, W., C. H. Andrewes and P. P. Laidlaw: A virus obtained from influenza patients. Lancet 1933, 66.

    Google Scholar 

  • Tomcsik, J.: Die Struktur der Bakteriengrenzflächen. Ergebn. med. Grundlagenforsch. 1, 1 (1956).

    Google Scholar 

  • Tomcsik, J.: Ein Versuch zur Analyse eigener experimenteller Arbeiten. Basel: Benno Schwabe & Co. 1960.

    Google Scholar 

  • Topacio, T., and R. R. Hyde: The behavior of rabbit virus Iii in tissue culture. Amer. J. Hyg. 15, 99 (1932).

    Google Scholar 

  • Traver, M. I., R. L. Northrop and D. L. Walker• Site of intracellular antigen production by myxoviruses. Proc. Soc. exp. Biol. (N.Y.) 104, 268 (1960).

    Article  CAS  Google Scholar 

  • Vogel, J., and A Shelokow: Adsorption-hemagglutination test for influenza virus in monkey kidney tissue culture. Science 126, 358 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Watson, B. K.: Fate of mumps virus in the embryonated egg as determined by specific staining with fluorescein labeled immune serum. J. exp. Med. 96, 653 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Watson, B. K.: Distribution of mumps virus in tissue cultures as determined by fluorescent labelled antiserum. Proc. Soc. exp. Biol. (N.Y.) 79, 222 (1952).

    Article  CAS  Google Scholar 

  • Watson, B. K.: Mixed infectious with influenza and mumps viruses in the chick embryo. Bull. N.Y. Acad. Med. 32, 169 (1956).

    Google Scholar 

  • Watson, B. K. and A. H. Cooxs: Studies of influenza virus infection in the chick embryo using fluorescent entibody. J. exp. Med. 99, 419 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Weller, T. H., and A. H. Coons: Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proc. Soc. exp. Biol. (N.Y.) 86, 789 (1954).

    Article  CAS  Google Scholar 

  • Wheelock, E. F., and I. Tamm: Mitosis and division in HeLa cells infected with influenza or Newcastle disease virus. Virology 8, 532 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Wheelock, E. F., and I. Tamm: Enumeration of cell infecting particles of Ncd virus by fluorescent entibody technique. J. exp. Med. 113,301 (1961 a).

    Google Scholar 

  • Wheelock, E. F., and I. Tamm: Effect of multiplicity of infection on Ncd virus-HeLa cell interaction. J. exp. Med. 113, 317 (1961 b).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hygiene-Institut, Universität Basel, Schweiz

    Hans Löffler

Authors
  1. Hans Löffler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Philadelphia, USA

    W. Henle

  2. Düsseldorf, Deutschland

    W. Kikuth

  3. San Francisco, USA

    K. F. Meyer

  4. Hamburg, Deutschland

    E. G. Nauck

  5. Basel, Schweiz

    J. Tomcsik

Rights and permissions

Reprints and permissions

Copyright information

© 1962 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Löffler, H. (1962). Die Gruppe der Myxoviren. Ihre Untersuchung mittels fluorescierender Antikörper. In: Henle, W., Kikuth, W., Meyer, K.F., Nauck, E.G., Tomcsik, J. (eds) Ergebnisse der Mikrobiologie Immunitätsforschung und Experimentellen Therapie. Current Topics in Microbiology and Immunology, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-42624-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-42624-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-02812-3

  • Online ISBN: 978-3-662-42624-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation