Zusammenfassung
Die vorliegende Übersicht stellt sich zur Aufgabe, einige neuere Forschungsergebnisse über die biologischen Ursachen des Virustropismus zu diskutieren, wie sie insbesondere bei Untersuchungen über den Infektionsmechanismus der Enteroviren erzielt wurden. Diese Virusgruppe ist während der letzten Jahre im Zuge der massiven Attacke gegen die Poliomyelitis intensiv studiert worden, vor allem das Poliovirus selbst, dann aber auch die Coxsackie- und die ECHO-Viren. Wieweit die an Enteroviren erworbenen Kenntnisse auf andere Gruppen der menschund tierpathogenen Virusarten (Lwoff, Horne und Tournier 1963) übertragen werden dürfen, muß dahingestellt bleiben. Trotz zahlreicher gemeinsamer Eigenschaften der Virusarten bestehen im einzelnen erhebliche biologische Unterschiede zwischen Enteroviren, Myxoviren, Poxviren, Adenoviren, Reoviren, Herpesviren, Arborviren, um nur die für den Arzt und den medizinischen Wissenschaftler wichtigsten Gruppen zu nennen. Jedenfalls sind unsere Kenntnisse über die Infektionsmechanismen dieser verschiedenen Virusarten alles andere als vollständig, namentlich wenn man das Geschehen auf der cellulären oder makromolekularen Ebene ins Auge faßt.
Die eigenen experimentellen Arbeiten der Autoren sowie die Zusammenstellung dieses Übersichtsartikels wurde ermöglicht durch Forschungsbeihilfen des United States Public Health Service (Research Career Program Award No. AI-K6-16296; Research Grant E-4729) und der American Cancer Society, Inc. (E-289).
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Literatur
Attardi, G., and J. Smith: Virus specific protein and a ribonucleic acid associated with ribosomes in poliovirus infected HeLa cells. Cold Spr. Harb. Symp. quant. Biol. 27, 271–292 (1962).
Bachtold, J. G., H. C. Bubel, and L. P. Gebhardt: The primary interaction of poliomyelitis virus with host cells of tissue culture origin. Virology 4, 582–589 (1957).
Baltimore, D., and R. M. Franklin: Preliminary data on a virus-specific enzyme system responsible for the synthesis of viral Rna. Biochem. biophys. Res. Commun. 9, 388–392 (1962).
Barron, S., R. M. Friedman, and C. E. Buckler. Properties of poliovirus inhibitor from monkey brain. Proc. Soc. exp. Biol. (N.Y.) 113, 107–110 (1963).
Bodian, D.: Poliomyelitis: pathogenesis and histopathology. In: Viral and Rickettsial Infections of Man, T. M. Rivers and F. L. Horsfall Jr., (eds.), pp. 479–498. Philadelphia: J. B. Lippencott Company 1958.
Brand, G., I. Brand: Evolution und „Transformation“ von Zellkulturen (cytologische, krebsbiologische, immunologische und virologische Forschungsergebnisse). Ergebn. Mikrobiol. 35, 265–299 (1962).
Brand, K. G., and J. T. Syverton: Hemagglutination test for species specificity of cultivated mammalian cells. Proc. Amer. Ass. Cancer Res. 3, 8–9 (1959).
Brand, K. G., and J. T. Syverton: Immunology of cultivated mammalian cells. I. Species specificity determined by hemagglutination. J. nat. Cancer. Inst. 24, 1007–1019 (1960).
Brand, K. G., and J. T. Syverton: Results of species-specific hemagglutination tests on „transformed“, nontransformed, and primary cell cultures. J. nat. Cancer Inst. 28, 147–157 (1962).
Cairns, H. J. F., and P. J. Mason: Production of influenza a virus in the cells of the allantois. J. Immunol. 71, 38–40 (1953).
Cartwright, S. F., and H. V. Thorne: Some applications of detergents to the study of the virus of foot-and-mouth disease. J. gen. Microbiol. 20, 61–77 (1959).
Crottin, P. W., and L. Pihlipson: The inactivation of enterovirus infectivity by the sulfhydryl reagent p-chloromercuribenzoate. J. exp. Med. 113, 713–734 (1961).
Cooney, M. K., L. C. McLaren, and H. Bauer: A newly recognized enterovirus with affinity for primary human amnion cells, isolated from cases of aseptic menigitis. Amer. J. Hyg. 75, 301–310 (1962).
Cooper, P. D.: The plaque assay of animal viruses. Advanc. Virus Res. 8, 319–378 (1961).
Cooper, S., and M. D. Zinder: The growth of an Rna bacteriophage: The role of Dna synthesis. Virology 18, 405–411 (1962).
Crowell, R. L., and J. T. Syverton: The mammalian cell-virus relationship. VI. Sustained infection of HeLa cells by Coxsackie B-3 virus and effect on superinfection. J. exp. Med. 113, 419–435 (1961).
Crowther, D., and J. L. Melnick: Studies on the inhibitory action of guanidine on polio-virus multiplication on cell cultures. Virology 15, 65–74 (1961).
Darnell, J. E.: Adsorption and maturation of poliovirus in single and multiply infected HeLa cells. J. exp. Med. 107, 633–641 (1958).
Darnell, J. E. and T. K. Sawyer: The basis for variation in susceptibility to poliovirus in HeLa cells. Virology 11, 665–675 (1960).
Darnell, J. E., Jr.: Early events in poliovirus infection. Cold Spr. Harb. Symp. quant. Biol. 27, 149–157 (1962).
Darnell, J. E. and L. Levintow: Poliovirus protein: Source of amino acids and time course of synthesis. J. biol. Chem. 235, 74–77 (1960).
Darnell, J. E. and L. Levintow, M. M. Thgren, and J. L. Hooper: The time course of synthesis of poliovirus Rna. Virology 13, 271–279 (1961).
Drake, J. W.: Interference and multiplicity reactivation in polioviruses. Virology 6, 244–264 (1958).
Dulbecco, R., and M. Vogt: Plaque formation and isolation of pure lines with poliomyelitis viruses. J. exp. Med. 99, 167–182 (1954).
Easterbrook, K. B.: Interference with the maturation of vaccinia virus by isatin-ß-thiosemicarbizone. Virology 17, 245–251 (1962).
Eggers, H. J., and A. B. Sabin: Factors determining pathogenicity of variants of Echo 9 virus for newborn mice. J. exp. Med. 110, 951–967 (1959).
Enders, J. R., T. H. Weller and F. C. Robbins: Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 109, 85–88 (1949).
Evans, C. A., P. H. Byatt, V. C. Chambers, and W. M. Smith: Gowth of neurotropic viruses in extraneural tissues. VI. Absence if in vivo multiplication of poliomyelitis virus types I and II after intratesticular inoculation of monkeys and other laboratory animals. J. Immunol. 72, 341–347 (1954).
Fazekas DE Groth, S.: Viropexis, the mechanism of influenza virus infection. Nature (Lond.) 162, 294 (1948).
Fenwick, M. L.: The influence of poliovirus infection on Rna synthesis in mammalian cells. Virology 19, 241–249 (1963).
Flanagan, J. F., and H. S. Ginsburg: Synthesis of virus-specific polymers in adenovirusinfected cells: Effect of 5-fluorodeoxyuridine. J. exp. Med. 116, 141–157 (1962).
Francis Jr., T., and L. W. Chu: The interaction in vitro between poliomyelitis virus and nervous tissue. Atti VI Congr. Intern. Microbiol. 3, 162–170 (1953).
Franklin, R. M., and D. Baltimore: Patterns of macromolecular synthesis in normal and virus-infected mammalian cells. Cold. Spr. Harb. Symp. quant. Biol. 27, 175–195 (1962).
Herrmann, E. C., Jr.: Plaque inhibition test for detection of specific inhibitors of Dna containing viruses. Proc. Soc. exp. Biol. (N.Y.) 107, 142–145 (1961).
Hershey, A. D.: Bacteriophages. In: Viral and Rickettsial Infections of Man, T. M. Rivers and F. L. Horsfall Jr. (eds.), 3rd. ed., pp. 172–198. Philadelphia: J. B. Lippincott Company 1959.
Holland, J. J.: Receptor affinities as major determinants of enterovirus tissue tropisms in humans. Virology 15, 312–326 (1961).
Holland, J. J.: Altered base ratios in HeLa cell Rna during poliovirus infection. Biochem. biophys. Res. Commun. 6, 196–200 (1961a).
Holland, J. J.: Irreversible eclipse of poliovirus by HeLa cells. Virology 16, 163–176 (1962).
Holland, J. J.: Altered base ratios in Rna synthesized during enterovirus infection of human cells. Proc. nat. Acad. Sci. (Wash.) 48, 2044–2051 (1962a).
Holland, J. J.: Depression of host-controlled Rna synthesis in human cells during poliovirus infection. Proc. nat. Acad. Sci. (Wash.) 49, 23–28 (1963).
Holland, J. J. and B. H. Noyer: Early stages of enteroviral infection. In: Basic mechanism of animal virus biology. Cold Spr. Harb. Symp. quant. Biol. 27, 101–111 (1962).
Holland, J. J., B. H. Noyer, L. C. McLaren, and J. T. Syverton: Enteroviral ribonucleic acid. I. Recovery from virus and assimilation by cells. J. exp. Med. 112, 821–839 (1960).
Holland, J. J., B. H. Noyer, L. C. McLaren, J. T. Syverton, and L. C. McLaren: The mammalian cell-virus relationships. II. Adsorption, reception, and eclipse of poliovirus by HeLa cells. J. exp. Med. 109, 487–504 (1959).
Holland, J. J., B. H. Noyer, L. C. McLaren, J. T. Syverton, and L. C. McLaren: The location and nature of enterovirus receptors in susceptible cells. J. exp. Med. 114, 161–171 (1961).
Holland, J. J., B. H. Noyer, L. C. McLaren, J. T. Syverton, L. C. McLaren, B. H. Hoyer, and J. T. Syverton: Enteroviral ribonucleic acid. II. Biological physical and chemical studies. J. exp. Med. 112, 841–864 (1960a).
Holland, J. J., B. H. Noyer, J. T. Syverton: Mammalian cell-virus relationships. Iii. Poliovirus production by non-primate cells exposed to poliovirus ribonucleic acid. Proc. Soc. exp. Biol. (N.Y.) 100, 843–845 (1959).
Holland, J. J., B. H. Noyer, J. T. Syverton: The mammalian cell-virus relationships. IV. Infection of naturally unsusceptible cells with enterovirus ribonucleic acid. J. exp. Med. 110, 65–80 (1959a).
Howes, D. W.: The growth cycle of poliovirus in cultured cells. II. Maturation and release of virus in suspended cell populations. Virology 9, 96–109 (1959).
Howes, D. W.: The growth cycle of poliovirus in cultured cells. Iii. The asynchronous response of HeLa cells multiply infected with type 1 poliovirus. Virology 9, 110–126 (1959a).
Howes, D. W. and J. L. Melnick: The growth cycle of poliovirus in monkey kidney cells. I. Maturation and release of virus in monolayer cultures. Virology 4, 97–108 (1957).
Hoyer, B. H., E. T. Bolton, R. A. Ormsbee, G. Lebouvier, D. G. Ritter, and C. L. Larson: Mammalian viruses and rickettsiae. Their purification and recovery by cellulose anion exchange columns has significant implications. Science 127, 859–863 (1958).
Hoyle, L.: The entry of myxoviruses into the cell. In: Basic mechanisms in animal virus biology. Cold Spr. Harb. Symp. quant. Biol. 27, 113–121 (1962).
Hoyle, L. and N. B. Finter: The use of influenza virus labelled with radiosulfur in studies of the early stages of the interaction of virus with the host cell. J. Hyg. (Lond.) 55, 290–297 (1957).
Hsluxo, G. D.: Effect of x-irradiation on Patas monkey kidney cell susceptibility to enteroviruses. Virology 7, 140–149 (1959).
Joklik, W. K., and J. E. Darnell Jr.: The adsorption and early fate of purified poliovirus in HeLa cells. Virology 13, 439–447 (1961).
Kaplan, A. S.: Comparison of susceptible and resistant cells to infection with poliomyelitis virus. Ann. N.Y. Acad. Sci. 61, 830–838 (1955).
Kunin, C. M.: Virus-tissue union and the pathogenesis of enterovirus infections. J. Immunol. 88, 556–569 (1962).
Kunin, C. M., and N. E. Halmagyi: The relative abundance of viral receptors, an explanation of the differential susceptibility of suckling and adult mice to Coxsackie B-1 infection. J. clin. Invest. 40, 1055–1056 (1961).
Levintow, L., and J. E. Darnell: A simplified procedure for purification of large amounts of poliovirus: Characterization and amino acid analysis of type 1 poliovirus. J. biol. Chem. 235, 70–73 (1960).
Kunin, C. M., M. M. Thoran, J. E. Darnell Jr., and J. L. Hooper: Effect of fluorophenylalanine and puromycin on the replication of poliovirus. Virology 16, 220–229 (1962).
Levy, H. B.: Intracellular sites of poliovirus production. Virology 15, 173–183 (1961).
Loddo, B., S. Diuntoni, A. Spanedda, G. Brutzo, and W. Ferrari: Guanidine conditioned infectivity of ribonucleic acid extracted from a strain of guanidine-dependent polio-1 virus. Nature (Lond.) 197, 315 (1963).
Low, R. J., and S. Barron: Poliovirus inhibitor from the central nervous system of the Rhesus monkey. Science 132, 622–633 (1960).
Lwoff, A., R. Dulbecco, M. Vogt, and M. Lwoff: Kinetics of the release of poliovirus from infected cells. Virology 1, 128–139 (1955).
Lwoff, A., R. Horne, and A. Tournier: System of viruses. In: Basic mechanisms in animal virus biology. Cold Spr. Harb. Symp. quant. Biol. 27, 51–55 (1963).
Maassab, H. F., and W. W. Ackermann: Nucleic acid metabolism of virus-infected HeLa cells. Ann. N.Y. Acad. Sci. 81, 29–37 (1959).
Maassab, H. F., P. C. Lon, and W. W. Ackermann: Growth characteristics of poliovirus in HeLa cells: Nucleic acid metabolism. J. exp. Med. 106, 641–648 (1957).
Mandel, B.: The use of sodium dodecylsulfate in studies on the interaction of poliovirus and HeLa cells. Virology 17, 288–294 (1962).
Mandel, B.: Early stages of virus-cell interaction as studied by using antibody. In: Basic mechanisms in animal virus biology. Cold Spr. Harb. Symp. quant. Biol. 27, 123–130 (1962a).
Manson, L. A., E. L. Rothstein, and G. W. Rake: Purification of poliovirus with fluorocarbon. Science 125, 546–547 (1957).
Mayer, M. M., H. J. Rapp, B. Roizman, S. W. Klein, K. M. Cowan, D. Lukens, C. E. Schwerdt, F. L. Schaffer, and J. Charney: The purification of poliomyelitis virus as studied by complement fixation. J. Immunol. 78, 435–455 (1957).
Mcbride, W. D.: Basic mechanisms in animal virus biology. Cold Spr. Harb. Symp. quant. Biol. 27, 131 (1963).
McLaren, L. C.: In Vorbereitung.
McLaren, L. C., J. J. Holland, and J. T. Syverton: The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origins. J. exp. Med. 109, 475–485 (1959).
McLaren, L. C., J. J. Holland, and J. T. Syverton: The mammalian cell-virus relationship. V. Susceptibility and resistance of cells in vitro to infection by Coxsackie A 9 virus. J. exp. Med. 112, 581–594 (1960).
McLaren, L. C., J. J. Holland, and J. T. Syverton: Cellular factors associated with susceptibility and resistance to enteroviruses. Nat. Cancer Inst. Monogr. No 7, Symposium: Analytic cell culture, p. 273–285, 1962.
Munieb, R., and G. N. Cohen: Incorporation d’analogues structuraux d’aminoacides dans les proteines bacteriennes au cours de leur synthese in vivo. Biochim. biophys. Acta (Amst) 31, 378–391 (1959).
Niu, M. C., C. C. Cordova, L. C. Liu, and C. L. Radbill: Rna induced biosynthesis of specific enzymes. Proc. nat. Acad. Sci. (Wash.) 48, 1964–1969 (1962).
Perry, R. P.: The cellular sites of synthesis of ribosomal and 4 S Rna. Proc. nat. Acad. Sci. (Wash.) 48, 2179–2186 (1962).
Perry, R. P.: Selective effects of actinomycin D on the intracellular distribution of Rna synthesis in tissue culture cells. Exp. Cell Res. 29, 400–406 (1963).
Philipson, L., P. A. Albertsson and E. Frick: The purification and concentration of viruses by aqueous polymer phase systems. Virology 11, 553–571 (1960).
Philipson, L., and P. W. Choppin: On the role of virus sulfhydryl groups in the attachment of enteroviruses to erythrocytes. J. exp. Med. 112, 455–478 (1960).
Philipson, L., and P. W. Choppin: Inactivation of enterovirus by 2, 3-Dimercaptopropanol (Bal). Virology 16, 405–413 (1962).
Pohjanpelto, P.: Stabilization of poliovirus by cystine. Virology 6, 472–487 (1958).
Pohjanpelto, P.: Stabilizing effect of cystine on antigenicity of poliovirus. Ann. Med. exp. Fenn. 40, 103–107 (1962).
Qdersin-Thiry, L.: Interaction between cellular extracts and animal viruses. I. Kinetic studies and some notes on the specificity of the interaction. Acta virol. 5, 141–152 (1961).
Qdersin-Thiry, L. and E. Nihoul: Interaction between cellular extracts and animal viruses. II. Evidence for the presence of different inactivators corresponding to different viruses. Acta virol. 5, 283–293 (1961).
Reich, E., and R. M. Franklin: Effect of mitomycin C on the growth of some animal viruses. Proc. nat. Acad. Sci. (Wash.) 47, 1212–1217 (1961).
Reich, E., R. M. Franklin, A. S. Shatkin, and E. L. Tatum: Effect of actinomycin D on cellular nucleic acid synthesis and virus production. Science 134, 556–557 (1961).
Richtsel, W. A., J. R. Dice, R. J. Mcalpine, E. A. Timm, I. W. Mclean Jr., G. J. Dixon, and F. M. Schabelsen: Antiviral effect of guanidine. Science 134, 558–559 (1961).
Roizman, B.: Preparation of high potency poliovirus in FL cell cultures at room temperature. Proc. Soc. exp. Biol. (N.Y.) 101, 410–411 (1959).
Rothstein, E. L., and L. A. Manson: Phosphorus incorporation into high molecular weight Rna of poliovirus-infected HeLa cells. Virology 9, 141–143 (1959).
Rubin, H., M. Baluda, and J. E. Hotchin: The maturation of western equine encephalomyelitis virus and its release from chick embryo cells in suspension. J. exp. Med. 101, 205–212 (1955).
Sabin, A. B.: Constitutional barriers to involvement of the central nervous system to certain viruses. Science 91, 84–87 (1941).
Sabin, A. B.: Constitutional barriers to involvement of the nervous system to certain viruses, with special reference to the role of nutrition. J. Pediat. 19, 596–607 (1941a).
Sabin, A. B.: Properties of attenuated polioviruses and their behavior in human beings Cellular biology, nucleic acids and viruses. Spec. Public. N.Y. Acad. Sci. 5, 113–137 (1957).
Salzman, N. P.: The rate of formation of vaccinia deoxyribonucleic acid and vaccinia virus. Virology 10, 150–152 (1960).
Salzman, N. P. and R. Z. Lockart: Alteration in ribonucleic acid metabolism resulting from poliomyelitis virus infection in HeLa cells. Biochim. biophys. Acta (Amst) 32, 572–573 (1959).
Salzman, N. P. and E. D. Sebring: Utilization of precursors for nucleic acid synthesis by human cell cultures. Arch. Biochem. 84, 143–150 (1959).
Salzman, N. P. and E. D. Sebring: The source of poliovirus Rna. Virology 13, 258–260 (1961).
Salzman, N. P. and E. D. Sebring, A. J. Shatkin, and E. D. Sebring: Viral protein and Dna synthesis in vaccinia virus-infected HeLa cell cultures. Virology 19, 542–550 (1963).
Schaffer, F. L.: Binding of proflavine by photoinactivation of poliovirus propagated in the presence of dye. Virology 18, 421–425 (1962).
Salzman, N. P. and E. D. Sebring, H. F. Moore, and C. E. Scnwerdt: Base composition of the ribonucleic acids of the three types of poliovirus. Virology 10, 530–537 (1960).
Salzman, N. P., E. D. Sebring, and C. E. Schwerdt: Purification and properties of poliovirus. Advanc. Virus Res. 6, 159–204 (1959).
Scharff, M. D., M. M. Thoren, N. F. Mcelvain, and L. Levintow: Interruption of polio-virus Rna synthesis by p-fluorophenylalanine and puromycin. Biochem. biophys. Res. Commun. 10, 127–132 (1963).
Schwerdt, C. E., and F. L. Schaffer: Purification of poliomyelitis viruses propagated in tissue sulture. Virology 2, 665–678 (1956).
Shatkin, A. J.: The formation of vaccinia virus protein in the presence of 5-fluorodeoxyuridine. Virology 20, 292–301 (1963).
Shatkin, A. J. and N. P. Salzman: Deoxyribonucleic acid synthesis in vaccinia-virus infected HeLa cells. Virology 19, 551–560 (1963).
Simon, E. H.: Evidence for the nonparticipation of Dna in viral Rna synthesis. Virology 13, 105–118 (1961).
Staehelin, M., and M. P. Gordon: Effects of halogenated pyrimidines on growth of tobacco mosaic virus. Biochem. biophys. Acta (Amst.) 38, 307–315 (1960).
Tamaoki, T., and G. C. Mueller: Synthesis of nuclear and cytoplasmic Rna of HeLa cells. Biochem. biophys. Res. Commun. 9, 451–454 (1962).
Taylor, J., and A. F. Graham: Purification of poliovirus labeled with radiophosphorus. Virology 6, 488–498 (1958).
Thorne, H. V.: Electrophoretic study of the interaction of radioactive poliovirus with components of cultured cells. J. Bact. 85, 1247–1255 (1963).
Thorne, H. V., and S. F. Cartwright: Reactions of the virus of foot-and-mouth diesease with cells and cell debris. Virology 15, 245–257 (1961).
Wallis, C., and J. L. Melnick: Magnesium chloride enhancement of cell susceptibility to poliovirus. Virology 16, 122–132 (1962).
Warner, J., M. J. Madden, and J. E. Darnell: The interaction of poliovirus Rna with Escherichia coli ribosomes. Virology 19, 393–399 (1963).
Watson, J. D., and F. H. C. Crick: The structure of Dna. Cold Spr. Harb. Symp. quant. Biol. 18, 123–133 (1953).
Zimmerman, E. F., M. Hetter, and J. E. Darnell: Rna synthesis in poliovirus-infected cells. Virology 19, 400–408 (1963).
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McLaren, L.C., Brand, G. (1964). Virustropismus. Neue Erkenntnisse aus Untersuchungen über die Enterovirus-Infektion der Zelle. In: Henle, W., Kikuth, W., Meyer, K.F., Nauck, E.G., Tomcsik, J. (eds) Ergebnisse der Mikrobiologie Immunitätsforschung und Experimentellen Therapie. Current Topics in Microbiology and Immunology, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-42622-7_4
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