The use of fluorescent antibody in the diagnosis and study of viral and rickettsial infections

  • Chien Liu
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 33)


In the last decade, with the advent of new virological and tissue culture technics, more viruses have been isolated than ever before. However, the diagnosis and study of viral infections in the laboratory is a painstaking task chiefly because of the submicroscopic size of the viral particles and the difficulty in detecting their presence. The development of the fluorescent antibody technic by Coons and associates (1941) which combines the specificity of immune reagents and the sensitivity of the ultraviolet light microscope has added a powerful tool to the armamentarium of virological research. In using this relatively simple technic, viral antigens can be localized precisely at the cellular level.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1960

Authors and Affiliations

  • Chien Liu
    • 1
  1. 1.Department of PediatricsUniversity of Kansas School of Medicine Kansas CityUSA

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