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The influence of various precursors on the concentration of energy-rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival

Der Einfluß verschiedener Prekursoren auf die Konzentration von Pyridinnukleotiden und energiereichen Phosphaten im Herzmuskel und seine mögliche Bedeutung für das Überleben in Anoxie

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Experimental Cardiac Hypertrophy and Heart Failure

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Summary

A special “anoxia test” was developed with isolated guinea pig atria to test influences on the anoxic energy balance. Adenine, ribose, nicotinic acid or nicotinamide added as precursors to nutrition solutions inhibit the loss of cardiac adenine and pyridine nucleotides during anoxia and improve the energy balance under aerobic and anaerobic conditions in the myocardium.

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References

  1. Delabar, U., M. Siess: Synthesis and degradation of NAD in guinea pig cardiac muscle. I. Basic Res. Cardiol. 74, p. 528–544 (1979), II. Basic Res. Cardiol. 74, p. 571-593 (1979).

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  2. Seifart, H. L: Funktionelle und biochemische Untersuchungen zur Anoxie-toleranz des Herzmuskels und ihrer pharmakologischen Beeinflußbarkeit. Naturwissenschaftl. Diss. Tübingen 1978.

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  3. Siess, M., H. I. Seifart: Anoxic energy production and contractile activity in mammalian cardiac muscle: Advances in Myocardiology (1979), Vol. 2. (Baltimore) Ed. Tajudin, M., B. Bhatia, H. H. Siddiqui, G. Rona (1979), in pres

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Authors and Affiliations

  1. Department of Pharmacology, University of Tuebingen, Wilhelmstr. 56, D-7400, Tuebingen, Germany

    Dr. H. I. Seifart, Prof. Dr. med. M. Siess & U. Delabar

Authors
  1. Dr. H. I. Seifart
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  2. Prof. Dr. med. M. Siess
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  3. U. Delabar
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Editor information

Editors and Affiliations

  1. Tübingen, Germany

    Ruthard Jacob (Prof. Dr.) (Prof. Dr.)

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© 1980 Springer-Verlag Berlin Heidelberg

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Seifart, H.I., Siess, M., Delabar, U. (1980). The influence of various precursors on the concentration of energy-rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival. In: Jacob, R. (eds) Experimental Cardiac Hypertrophy and Heart Failure. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-41468-2_8

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  • DOI: https://doi.org/10.1007/978-3-662-41468-2_8

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-0577-3

  • Online ISBN: 978-3-662-41468-2

  • eBook Packages: Springer Book Archive

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