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Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell

Funktionelles Verhalten subzellulärer Strukturen des Myokards während Sauerstoffmangel in Relation zum Metabolitstatus der Herzmuskelzelle

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Experimental Cardiac Hypertrophy and Heart Failure

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Summary

The functional behaviour of membrane systems of the cardiac cell during oxygen deficiency was analyzed and the alterations were related to the metabolic state of the tissue as an index of injury.

  1. 1

    The retention function of the cell membrane for proteins. With increasing energy deficiency the cardiac sarcolemma loses its ability to retain macromolecules (myoglobin, enzymes) within the cell. Close correlations exist between protein release and oxygen supply as well as ATP content of the tissue.

  2. 2

    Function of isolated mitochondria after ischemia. In parallel with a strong impairment of oxidative phosphorylation (decrease of QO2, RCI values, phosphorylation rates) the Ca++-transporting activity of mitochondria is continuously depressed with decreasing myocardial ATP.

  3. 3

    Function of isolated sarcoplasmic reticulum after ischemia. With breakdown of high energy phosphates during ischemia rate and extent of Ca++ binding both decrease markedly.

Supported by the Deutsche Forschungsgemeinschaft, SFB 89 — Kardiologie Goettingen.

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Authors and Affiliations

  1. Institute of Physiology I, University of Goettingen, Humboldtallee 7, D-3400, Goettingen, Germany

    P. G. Spieckermann (Prof. Dr. med.), M. M. Gebhard, G. G. Göring, H. Kahles, V. A. Mezger, C. J. Preuße & M. Stellwaag

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  1. P. G. Spieckermann
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  2. M. M. Gebhard
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  3. G. G. Göring
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  4. H. Kahles
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  5. V. A. Mezger
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  6. C. J. Preuße
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  7. M. Stellwaag
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Editor information

Editors and Affiliations

  1. Tübingen, Germany

    Ruthard Jacob (Prof. Dr.) (Prof. Dr.)

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© 1980 Springer-Verlag Berlin Heidelberg

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Spieckermann, P.G. et al. (1980). Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell. In: Jacob, R. (eds) Experimental Cardiac Hypertrophy and Heart Failure. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-41468-2_14

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  • DOI: https://doi.org/10.1007/978-3-662-41468-2_14

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-0577-3

  • Online ISBN: 978-3-662-41468-2

  • eBook Packages: Springer Book Archive

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