Abstract
Until 1975, marrow grafting following high-dose chemotherapy combined with total body irradiation (TBI) was considered only for patients with acute leukemia in advanced relapse when all other therapy had failed. 110 such patients were given marrow grafts from HLA-identical siblings in Seattle, and 10% are alive in unmaintained remission between 9 and 14 years without further treatment (1). Even though many patients died from graft-versus-host disease (GVHO). interstitial pneumonias and other infections, it was clear that leukemic relapse was a major complication after marrow grafting, occurring at an actuarial rate of 75% (2). As far as could be determined, leukemic recurrences usually originated from host cells which were apparently resistant to the high-dose chemoradiotherapy used to prepare the patients for transplantation. This was true both for patients with acute lymphoblastic (ALL) and acute non-lymphoblastic leukemia (ANL) in advanced relapse.
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© 1985 Springer Science+Business Media New York
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Storb, R. (1985). Marrow Grafting for Leukemia. In: Hinterberger, W., Barrett, A.J., Lechner, K., Deutsch, E. (eds) 11th Annual meeting of the EBMT. Experimental Hematology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-40457-7_3
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DOI: https://doi.org/10.1007/978-3-662-40457-7_3
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