Abstract
HA antigen distribution, as assessed with 11 HA alloantisera on a group of activated and nonactivated cells, confirm their non-ubiquitous distribution as well as their epitopic regulation by IL2, IFNα, and γ, which is evidence of their modulation from the existing gene. From their expressivity on a group of pathologic cells, such as chronic leukemia (CLL), acute leukemias (ANLL and T or NT ALL), we can assess their importance at an early stage of cellular differentiation, as confirmed by the observed marker correlation CD9+/HA+. Also, analysis of the transfectant cells, hybridized with a subfamily probe of a class I gene recognized by an HA2 alloserum, brings evidence of the existence of a functional gene encoding non-HLA molecules independent from HLA molecules.
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Fauchet, R., Boscher, M., Genetet, N., Bouhallier, O., Genetet, B., Paul, P. (1989). Cellular Distribution and Expression Regulation of HA Molecules (New Class I-Like Antigens). In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_46
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DOI: https://doi.org/10.1007/978-3-662-39946-0_46
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