Abstract
Cytotoxic T lymphocytes (CTL) can be raised by stimulating in vitro the peripheral blood mononuclear cells (PBMC) of HLA-B27-positive normal individuals (B27+AS−) with autologous cells “modified” by cross-reactive bacterial antigens or modifying factor. These CTL specifically lyse PBMC from HLAB27-positive patients with ankylosing spondylitis (B27+AS+) but not PBMC from HLA-B27-negative AS patients (B27−AS+) or from HLA-B27-positive (B27+AS−) or -negative (B27−AS−) normal controls. Studies with HLA-loss variants of a B27-positive lymphoblastoid cell line have shown that mutants that no longer express B27 cannot be “modified” with factor and they fail to function as targets in the CTL assay. These results suggest that CTL can recognize certain bacterial antigens in the context of HLA-B27.
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© 1989 Springer Science+Business Media New York
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Edwards, C.M., Sullivan, J.S., Upfold, L.I., Geczy, A.F. (1989). CTL Recognize Certain Bacterial Antigens in Association with HLA-B27. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_23
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DOI: https://doi.org/10.1007/978-3-662-39946-0_23
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