Abstract
The presence of allogeneic Ag-specific T-suppressor inducer cells with in vivo activity has been demonstrated by Hutchinson (1), using a rat renal allograft model. We now demonstrate the presence of in vivo and in vitro T-suppressor inducer activity in the W3/25+ (CD4+) subset of lymphocytes from WF strain rats rejecting LEW strain heterotopic cardiac allografts transplanted 5 days previously. Adoptive transfer of 2 to 4 × 107 of these immune day 5 W3/25+ [d5 W3/25+] splenocytes, or their sonicates 7 days prior to transplantation, prolongs allograft survival two- to threefold in unmodified or irradiated hosts (200 to 300 rads). This prolongation is specific for the donor strain (Table 1).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hutchinson IV. Suppressor T cells in allogeneic models. Transplantation 1986; 41 (5): 547.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rothstein, D.M., Frankel, A.H., Kwok, C., Milford, E.L., Carpenter, C.B. (1989). Allogeneic Rat T-Suppressor Inducer Cells with In Vivo and In Vitro Activity. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_210
Download citation
DOI: https://doi.org/10.1007/978-3-662-39946-0_210
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38980-5
Online ISBN: 978-3-662-39946-0
eBook Packages: Springer Book Archive