Abstract
The complexity and fine specificity of the allospecific T-cell response generated against the human HLA-A2.1 molecule and the characterization of the antigenic determinants that anti-HLA-A2 alloreactive CTLs recognize in the molecule has been analyzed using as targets, cell lines expressing HLA-A2 CTL-variants and the human rhabdomyosarcoma cell line (RD) transfected and expressing HLA-A2 mutants obtained by site-directed mutagenesis.
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Santos-Aguado J, Crimmins MAV, Mentzer SJ, Strominger JL, Burakoff SJ. Molecular characterization and fine specificity of anti-HLA-A2 allospecific CTL response. Manuscript in preparation.
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Santos-Aguado, J., Crimmins, M.A.V., Mentzer, S.J., Strominger, J.L., Burakoff, S.J. (1989). Molecular Characterization of Allospecific Cytotoxic T-Lymphocyte Recognition Sites in the HLA-A2 Molecule Using Oligonucleotide-Generated Site-Specific Mutants. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_14
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DOI: https://doi.org/10.1007/978-3-662-39946-0_14
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