Abstract
The HLA-DP molecules were the last of the HLA class II molecules to be identified. These molecules were originally detected by the primed lymphocyte test. Their low representation on cells compared to DR and DQ molecules, and the difficulty in generating DP-specific antibodies have resulted in these molecules being the least well studied with respect to both disease associations and biochemical and molecular biologic characterization. Indeed, very few DP genes have been sequenced to date.
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References
Tieber VL, Abruzzini LF, Didier DK, Schwartz BD, Rotwein P. Complete characterization and sequence of an HLA class II DRII chain eDNA from the DR5 haplotype. J Biol Chem 1986; 261: 2738.
Schiffenbauer J, Didier DK, Klearman M, Rice K, Shuman S, Tieber VL, et al. Complete sequence of the HLA-DQa and DQP eDNA from a DR5/DQw3 cell line. J Immunol 1987; 139: 228.
Gustafsson K, Widmark E, Jonssdon AK, Servenius B, Sachs DH, Larhammar D, et al. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. J Biol Chem 1987; 262: 8778.
Ando A, Inoko H, Kimura M, Ogata S, Tsuji K. Isolation and allelic polymorphism of eDNA clones and genomic clones of HLA-DP heavy and light chains. Human Immunol 1986; 17: 355.
Long E, Gorski J, Mach B. Structural relationship of the SB (3-chain gene to the HLA-D-region genes and murine I region genes. Nature 1984; 310: 233.
Kappes DJ, Arnot D, Okada K, Strominger JL. Structure and polymorphism of the HLA class II SB light chain genes. EMBO J 1984; 3: 2985.
Roux-Dosseto M, Auffray C, Lillie JW, Boss JM, Cohen D, DeMars R, et al. Genetic mapping of a human class II antigen ß-chain cDNA clone to the SB region of the HLA complex. Proc Natl Acad Sci USA 1983; 80: 6036.
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© 1989 Springer Science+Business Media New York
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Rice, K. et al. (1989). Sequence of a DPβ cDNA from the DR5, DQw7, DPw4b Cell Line Swei. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_121
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DOI: https://doi.org/10.1007/978-3-662-39946-0_121
Publisher Name: Springer, Berlin, Heidelberg
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