Skip to main content

Der Einfluß der Durchblutung auf die Resorption von Arzneimitteln aus dem Jejunum der Ratte

  • Chapter
Naunyn Schmiedebergs Archiv für Pharmakologie
  • 2 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Barry, R.J. C, M.J. Jackson, and D.H. Smyth: Transfer of propionate by rat small intestine in vitro. J. Physiol. (Lond.) 182, 150 (1966).

    CAS  Google Scholar 

  • Cochran, W.G.: Analysis of covariance: its nature and uses. Biometrics 13, 261 (1957).

    Article  Google Scholar 

  • Condon, N.E.: A modification of the conventional mercury manometer for blood-pressure recordings. Brit. J. Pharmacol. 6, 19 (1951).

    CAS  Google Scholar 

  • Csernay, L., P. Wolf u. V. Varro: Der Kreislaufgradient im Dünndarm. Z. Gastroenterol. 3, 261 (1965).

    Google Scholar 

  • Polkow, B.: Regional adjustments of intestinal blood flow. Gastroenterology 52, 423 (1967).

    Google Scholar 

  • Folkow, B., D.H. Lewis, O. Lundgren, S. Mellander, and I. Wallentin: The effect of sympathetic vasoconstrictor fibres on the distribution of capillary blood flow in the intestine. Acta physiol. scand. 61, 458 (1964).

    Article  CAS  PubMed  Google Scholar 

  • Forth, W.: Eisen-und Kobalt-Resorption am perfundierten Dünndarmsegment. In: Staib, W., u. R. Scholz: Stoffwechsel der isoliert perfundierten Leber, S. 242–250. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • Furukawa, E., u. W. Rummel: Vergleichende Untersuchung von Resorption und Ausscheidung tritiummarkierter Herzglykoside. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 263, 206 (1969).

    Article  CAS  Google Scholar 

  • Geigy: Documenta Geigy: Wissenschaftliche Tabellen, 6. Aufl. Basel: J.R. Geigy 1960.

    Google Scholar 

  • Hogben, C.A.M., D.J. Tocco, B.B. Brodie, and L.S. Schanker: On the mechanism of intestinal absorption of drugs. J. Pharmacol. exp. Ther. 125, 275 (1959).

    CAS  PubMed  Google Scholar 

  • Krüger-Thiemer, E., u. B. Schlender: Die Lösung chemotherapeutischer Probleme durch programmgesteuerte Ziffernrechenautomaten. (2. Mitteilung: Gleichungsparameter, Vertrauensgrenzen, Gauß-Newton-Iterationsverfahren). Arzneimittel-Forsch. 13, 891 (1963).

    Google Scholar 

  • — u. J. Seydel: Die Lösung chemotherapeutischer Probleme durch programmgesteuerte Ziffernrechenautomaten. (3. Mitteilung: Löslichkeit von Sulfanil-amiden, Algol-Programm.) Arzneimittel-Forsch. 13, 894 (1963).

    Google Scholar 

  • Kurz, H., u. G. Friemel: Artspezifische Unterschiede der Bindung an Plasmaproteine. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 257, 35 (1967).

    Article  CAS  Google Scholar 

  • Lee, J.S., and K.M. Duncan: Lymphatic and venous transport of water from rat jejunum: a vascular perfusion study. Gastroenterology 54, 559 (1968).

    CAS  PubMed  Google Scholar 

  • Lembeck, F., K.-Fr. Sewing u. D. Winne: Der Einfluß von 5-Hydroxytryptamin auf die Resorption von Tritium-Wasser (HTO) aus dem Dünndarm der Ratte. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 100 (1964).

    Article  CAS  Google Scholar 

  • Linder, A.: Statistische Methoden für Naturwissenschaftler, Mediziner und Ingenieure, 3. Aufl. Basel: Birkhäuser 1960.

    Book  Google Scholar 

  • Lundgren, O.: Studies on blood flow distribution and countercurrent exchange in the small intestine. Acta physiol. scand. Suppl. 303, 1 (1967).

    Article  CAS  PubMed  Google Scholar 

  • Nelson, R.A., and R.J. Beargie: Relationship between sodium and glucose transport in canine jejunum. Amer. J. Physiol. 208, 375 (1965).

    CAS  PubMed  Google Scholar 

  • Nogami, H., and T. Matsuzawa: Studies on absorption and excretion of drugs. I. Kinetics of penetration of acidic drug, salicylic acid, through the intestinal barrier in vitro. Chem. pharm. Bull. 9, 532 (1961).

    CAS  Google Scholar 

  • — Studies on absorption and excretion of drugs. II. Kinetics of penetration of basic drug, aminopyrine, through the intestinal barrier in vitro. Chem. pharm. Bull. 10, 1055 (1962).

    Article  CAS  Google Scholar 

  • Ochsenfahrt, H., u. D. Winne: Darmdurchblutung und Resorption von Arzneimitteln. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 260, 184 (1968a).

    Article  CAS  Google Scholar 

  • — Intestinal blood flow and drug absorption from the rat jejunum. Life Sci. 7, 493 (1968b).

    Article  CAS  PubMed  Google Scholar 

  • Reininger, E.J., and L.A. Sapirstein: Effect of digestion on distribution of blood flow in the rat. Science 126, 1176 (1957).

    Article  CAS  PubMed  Google Scholar 

  • Robinson, J.W.L., J.-A. Antonioli, and V. Mirkovitch: The intestinal response to ischaemia. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 178 (1966).

    Article  CAS  Google Scholar 

  • Ross, G., F.N. White, A.W. Brown, and A. Kolin: Regional blood flow in the rat. J. appl. Physiol. 21, 1273 (1966).

    CAS  PubMed  Google Scholar 

  • Schanker, L.S.: Passage of drugs across body membranes. Pharmacol. Rev. 14. 501 (1962).

    CAS  PubMed  Google Scholar 

  • — Physiological transport of drugs. Advanc. Drug. Res. 1, 71 (1964).

    CAS  Google Scholar 

  • — P.A. Shore, B.B. Brodie, and C.A.M. Hogben: Absorption of drugs from the stomach. I. The rat. J. Pharmacol. exp. Ther. 120, 528 (1957).

    CAS  Google Scholar 

  • — D.J. Tocco, B.B. Brodie, and C.A.M. Hogben: Absorption of drugs from the rat small intestine. J. Pharmacol. exp. Ther. 123, 81 (1958).

    CAS  PubMed  Google Scholar 

  • Scholtan, W.: Bestimmungsmethoden und Gesetzmäßigkeiten der Eiweißbindung von Sulfonamiden und Penicillinen. In: Antibiotica et Chemotherapia, Bd. 12, S. 103–134. Basel-New York: S. Karger 1964.

    Google Scholar 

  • Shore, P.A., B.B. Brodie, and C.A.M. Hogben: The gastric secretion of drugs: a pH partition hypothesis. J. Pharmacol. exp. Ther. 119, 361 (1957).

    CAS  PubMed  Google Scholar 

  • Smyth, D.H.: Alimentary absorption of drugs: physiological considerations. In Binns, T.B.: Absorption and distribution of drugs, pp. 1–15. Edinburgh-London: Livingstone 1964.

    Google Scholar 

  • Spector, W.S.: Handbook of Biological Data. Philadelphia-London: W.B. Saunders Comp. 1956.

    Google Scholar 

  • Takacs, L., and V. Vajda: Effect of serotonin on cardiac output and organ blood flow of rats. Amer. J. Physiol. 204, 301 (1963).

    CAS  PubMed  Google Scholar 

  • Varro, V., G. Blaho, L. Csernay, I. Jung, and F. Szarvas: Effect of decreased local circulation on the absorptive capacity of a small-intestine loop in the dog. Amer. J. dig. Dis. 10, 170 (1965).

    Article  CAS  PubMed  Google Scholar 

  • Weber, E.: Grundriß der biologischen Statistik, 5. Aufl. Jena: VEB G.Fischer 1964.

    Google Scholar 

  • Williams, J.H., M. Mager, and E.D. Jacobson: Relationship of mesenteric blood flow to intestinal absorption of carbohydrates. J. Lab. clin. Med. 63, 853 (1964).

    CAS  PubMed  Google Scholar 

  • Winne, D.: Der Einfluß einiger Pharmaka auf die Darmdurchblutung und die Resorption tritiummarkierten Wassers aus dem Dünndarm der Ratte. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 254, 199 (1966).

    Article  CAS  Google Scholar 

  • —, u. H. Ochsenfahrt: Die formale Kinetik der Resorption unter Berücksichtigung der Darmdurchblutung. J. theor. Biol. 14, 293 (1967).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ochsenfahrt, H., Winne, D. (1969). Der Einfluß der Durchblutung auf die Resorption von Arzneimitteln aus dem Jejunum der Ratte. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_170

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-39718-3_170

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38809-9

  • Online ISBN: 978-3-662-39718-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics