Abstract
Autoimmune phenomena are of major importance in the pathogenesis of the main paraneoplastic diseases in humans. The autoimmune process is probably triggered by oncogenic antigens, which are cross-reactive or identical with certain neural antigens. Despite the known pathomechanism these syndromes are still considered as non-treatable. We report two cases of paraneoplastic cerebellar degeneration, in which intensive immunosuppression with cytostatics lead to considerable neurological improvement.
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Reiber H., Felgenhauer K. (1987) Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system; Clin. Chim. Acta 163: 319–328
Sindic C. J. M. et al. (1981) The clinical relevance of ferritin concentration in the cerebrospinal fluid; J. Neurol. Neurosurg Psychiatry 44: 329–33
Wick et al. (1988) Ferritin in cerebrospinal fluid differentation between central nervous system hemorrhage and traumatic spinal puncture; J. Clin. Pathol. 41: 809
Cann AJ, Churcher MJ, Boyd M, O’Brien W, Zhao JQ, Zack J, Chen ISY (1992) The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism. J Virol 66: 305–309
Rolfs A, Schuller I, Finckh U, Weber-Rolfs I (1992). PCR: Clinical diagnostics and research. 1992, Springer Heidelberg, New York
Rolfs A, Schumacher HC (1990). Early findings in the cerebrospinal fluid of patients with HIV-1 infection of the central nervous system. New Engl J Med 323:418–419
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© 1992 Springer-Verlag Berlin Heidelberg
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Stark, E. et al. (1992). Cerebrospinal fluid analysis Clinical neurochemistry. In: Abstracts of the 65th congress of the German Society of Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39699-5_7
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DOI: https://doi.org/10.1007/978-3-662-39699-5_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38797-9
Online ISBN: 978-3-662-39699-5
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