Abstract
After oral application of diphenhydramine (I), 2,2-diethyl-allyl-acetamide (II), carbromal (III) and paracetamol (IV) in man, equilibration of drug concentrations between blood plasma and resting saliva was measured up to 24 hrs. The drug concentrations were determined by means of gaschromatographic-mass fragmentographic methods using single-ion-detection (SID) at characteristic m/e values of these compounds (m/e 165 (I), m/e 126 (II), m/e 167 (III) and m/e 109 (IV) after methylation by means of diazomethane).
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© 1978 Springer-Verlag Berlin Heidelberg
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Eckard, R., Ening, R., Ening, W. (1978). Mass Fragmentographic Study of the Time Course of Different Drugs with Respect to the Plasma-Salivary Distribution Coefficient in Man. In: Deutsche Pharmakologische Gesellschaft. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39532-5_53
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DOI: https://doi.org/10.1007/978-3-662-39532-5_53
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38666-8
Online ISBN: 978-3-662-39532-5
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