Abstract
The purpose of the present account of enzymatic reactions sensitive to penicillins, cephalosporins and other antibacterial agents is to complement the preceding chapter by providing an account of recent discoveries of the precise reactions inhibited by these agents. Bacterial cell walls are synthesized in three distinct stages which occur at three different sites in the bacterial cell. Antibiotics are known which specifically inhibit the activity of enzymes at each of these sites.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, J. S., M. Matsuhashi, M. A. Haskin, and J. L. Strominger: Lipidphosphoacetylmuramyl-pentapeptide and lipid-phosphodisaccharide-pentapeptide: Presumed membrane transport intermediates in bacterial cell wall synthesis. Proc. Natl. Acad. Sci. U.S. 53, 881 (1965).
Anderson, J. S., P. M. Meddow, M. A. Haskin, and J. L. Strominger: Biosynthesis of the peptidoglycan of bacterial cell walls. 1. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus. Arch. Biochem. Biophys. 116, 487 (1966).
Araki, Y., A. Shimada, and E. Ito: Effect of penicillin on cell wall mucopeptide synthesis in a Escherichia coli particulate system. Biochem. Biophys. Res. Commun. 23, 518 (1966).
Fitz-James, P., and R. Hancock: The initial structural lesion of penicillin action in Bacillus megaterium. J. Cell Biol. 26, 657 (1965).
IzAxI, K.: Purification and properties of the penicillin sensitive D-alanine carboxypeptidase. Federation Proc. (Abstr.) 26, 388 1967.
IzAki, K., M. Matsuhashi, and J. L. Strominger: Glycopeptide transpeptidase and D-alanine carboxypeptidase: Penicillin-sensitive enzymatic reactions. Proc. Natl. Acad. Sci. U.S. 55, 656 (1966).
Lark, C., D. Bradley, and K. G. Lark: Further studies on the incorporation of D-methionine into the bacterial cell wall. Its incorporation into the R-layer and the structural consequences. Biochim. et Biophys. Acta 78, 278 (1963).
Martin, H. H.: Composition of the mucopolymer in cell walls of the unstable and stable form of Proteus mirabilis. J. Gen. Microbiol. 36, 441 (1964a).
Martin, H. H.: Chemical composition of cell wall mucopolymer from penicillin spheroplasts and normal cells of Proteus mirabilis. Abstracts, Sixth Internat. Congr. of Biochem., New York 1964b, p. 518.
Siewert, G., and J. L. Strominger: Bacitracin: An inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in biosynthesis of the peptidoglycan of bacterial cell walls. Proc. Natl. Acad. Sci. U.S. 57 161 (1967).
Strominger, J. L., E. Ito, and R. H. Thren: Competitive inhibition of enzymatic reactions by oxamycin. J. Am. Chem. Soc. 82, 998 (1960).
Strominger, J. L., K. Izaki, M. Matsuhashi, and D. J. Tipper: Peptidoglycan transpeptidase and D-alanine carboxypeptidase: Penicillin sensitive enzymatic reactions. Federation Proc. (Symposium) 26, 9 1967.
Tipper, D. J., and J. L. Strominger: Mechanism of action of penicillins: A proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc. Natl. Acad. Sci. U.S. 54, 1133 (1965).
Weidel, W., and H. Pelzer: Bagshaped macromolecules — a new outlook on bacterial cell walls. Advances in Enzymol. 26, 193 (1964).
Wise, E. M., and J. T. Park: Penicillin: Its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis. Proc. Natl. Acad. Sci. U.S. 54, 75 (1965).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Strominger, J.L. (1967). Enzymatic Reactions in Bacterial Cell Wall Synthesis Sensitive to Penicillins, Cephalosporins, and Other Antibacterial Agents. In: Gottlieb, D., Shaw, P.D. (eds) Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38439-8_62
Download citation
DOI: https://doi.org/10.1007/978-3-662-38439-8_62
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-37649-2
Online ISBN: 978-3-662-38439-8
eBook Packages: Springer Book Archive