Antibiotics pp 631-635 | Cite as


  • F. Edmund HunterJr.
  • Lois S. Schwartz


The isolation of and chemical studies on valinomycin from Streptomyces fulvissimus were first reported by Brockmann and Schmidt-Kastner (1955). Shemyakin et al. (1965) reported its structure to be a cyclododecadepsipeptide consisting of three repetitions of the sequence, d-valine, l-lactic acid, l-valine, and d-α-hydroxyvaleric acid. The empirical formula is C54H90O18N6 with a molecular weight of 1110. The structural formula is indicated in Fig. 1.


Trypanosoma Brucei Phenazine Methosulfate Structure Activity Relation Permeant Anion Terium Tuberculosis 
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  1. Azzi, A., and G. F. Azzone: Potassium-transport-linked swelling induced by valinomycin in liver mitochondria. Biochem. J. 96, 1 C (1965).Google Scholar
  2. Baltscheffsky, H.: Electron transport and phosphorylation in light induced phosphorylation. In: Biological structure and function (T. W. Goodwin and O. Lindberg, eds.). Iubs/Iub International Symposium, Stockholm 1960, vol. II, p. 431. New York: Academic Press 1961.Google Scholar
  3. Baltscheffsky, H., and B. Arwidsson: Evidence for two phosphorylation sites in bacterial cyclic photphosphorylation. Biochim. et Biophys. Acta 65, 425 (1962).Google Scholar
  4. Brockmann, H., and G. Schmidt-Kastner: ValinOmyCin-Mitteilungen über Antibiotica aus Actinomyceten. Chem. Ber. 88, 57 (1955).CrossRefGoogle Scholar
  5. Brown, K., J. Brennan, and C. Kelley: An antifungal agent identical with valinomycin. Antibiotics & Chemotherapy 12, 482 (1962).Google Scholar
  6. Chappell, J. B., and A. R. Crofts: Ion transport and reversible volume changes of isolated mitochondria. Symposium on the Regulation of Metabolic Processes in Mitochondria, Bari, Italy, April 1965. (In press, 1966).Google Scholar
  7. Harris, E. J., R. Cockrell, and B. C. Pressman: Induced and spontaneous movements of potassium into mitochondria. Biochem. J. (in press, 1966).Google Scholar
  8. Hofer, M., R. Cockrell, and B. C. Pressman: Effect of induced mitochondrial K+ transport on Atp synthesis. Federation Proc. Abstract, March (1966).Google Scholar
  9. Hunter, J R.F.E.: The role of electron transfer and phosphorylation in various parts of the electron transport chain incontrol of mitochondrial swelling. Symposium V. Fifth Internat. Congr. of Biochemistry, Moscow, 1961, p. 287. Oxford: Pergamon Press 1963.Google Scholar
  10. Lynn, W. S., and R. H. Brown: Role of anions in mitochondrial swelling and contraction. Biochim. et Biophys. Acta 110, 445 (1965a).Google Scholar
  11. Lynn, W. S., and R. H. Brown: Cation exchange and oxidative phosphorylation in mitochondria. Biochim. et Biophys. Acta 110, 459 (1965b).Google Scholar
  12. Mcmurray, W., and R. W. Begg: Effect of valinomycin on oxidative phosphorylation. Arch. Biochem. Biophys. 84, 546 (1959).CrossRefGoogle Scholar
  13. Mitchell, P., and J. Moyle: Stoichiometry of proton translocation through the respiratory chain and adenosinetriphosphatase systems of rat liver mitochondria. Nature 208, 147 (1965).PubMedCrossRefGoogle Scholar
  14. Moore, C., and B. C. Pressman: Mechanism of action of valinomycin on mitochondria. Biochem. Biophys. Research Commun. 15, 562 (1964).CrossRefGoogle Scholar
  15. Ogata, E., and H. Rasmussen: Valinomycin and mitochondrial ion transport. Biochemistry 5, 57 (1966).PubMedCrossRefGoogle Scholar
  16. Pressman, B. C.: Specific inhibitors of energy transfer. In: Energy-linked functions of mitochondria (B. Chance, ed.), p. 181. New York: Academic Press 1963.Google Scholar
  17. Pressman, B. C.: Induced active transport of ions in mitochondria. Proc. Natl. Acad. Sci. U. S. 53, 1076 (1965a).CrossRefGoogle Scholar
  18. Pressman, B. C.: Mechanochemical oscillations of mitochondria. Abstract, Division of Biological Chemistry, American Chemical Society Meeting, September 1965 b.Google Scholar
  19. Pressman, B. C.: Mitochondrial light scattering changes associated with induced ion transport. J. Cell. Biol. 27, 79A (1965c).Google Scholar
  20. Pressman, B. C.: Ion transport induction by valinomycin and related antibiotics. Abstract, Symposium on Mechanism of Fungicides and Antibiotics, Reinhardsbrun, East Germany, 1966.Google Scholar
  21. Shemyakin, M. M., E. I. Vinogradova, M. Y. Feignia, N. A. Aldanova, N. F. LoGinova, I. D. Ryabovia, and I. A. Pavlenko: The structure-antimicrobial relation for valinomycin depsipeptides. Experientia 21, 548 (1965).Google Scholar
  22. Werner, C. E., E. J. Harris, and B. C. Pressman: Relationship of the light scattering properties of mitochondria to the metabolic state in ascites tumor cells. Abstract, Biophysics Society Meeting, Boston, Feb. 1966.Google Scholar

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© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • F. Edmund HunterJr.
  • Lois S. Schwartz

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