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Antibiotics pp 621-630 | Cite as

Patulin

  • Jaswant Singh

Abstract

Patulin, 4-hydroxy-4H-furo [3,2c] pyran-2(6 H)-one, has an empirical formula C7H6O4 and molecular weight 154. It has been isolated as colorless crystals, melting at 110.5°C, and is optically inactive. The ultraviolet absorption spectrum of the antibiotic has a single peak at 276 mμ. Patulin is unstable in alkali and loses biological activity (Chain et al., 1942; Atkinson, 1942; Hooper et al., 1944; and Karow and Foster, 1944), but it is stable in acid (Chain et al., 1942). The antibiotic was isolated from several species of Penicillium and Aspergillus, and a species of Gymnoascus. Details of the history of discovery of patulin and the various names given to it can be found in the reviews by Florey et al. (1949) and Singh (1966). Woodward and Singh (1949, 1950) elucidated its chemical structure (Fig. 1).

Keywords

NADH Oxidase Respiratory Inhibition Antibacterial Substance Antibiotic Substance Ultraviolet Absorption Spectrum 
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© Springer-Verlag Berlin Heidelberg 1967

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  • Jaswant Singh

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