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Antibiotics pp 613-616 | Cite as

Nigericin

  • Paul D. Shaw
Chapter

Abstract

Nigericin was isolated from an unidentified streptomycete by Harned et al. (1951). Subsequently the producing organism was reported to be Streptomyces “Nig-1” (Benedict, 1953). The antibiotic has the empirical formula C39H69O11. It forms a monosodium salt and has one —OCH3 group. Nigericin inhibits grampositive bacteria at levels below 0.5 µg/ml, but levels above 60 µg/ml are required to inhibit gram- negative bacteria such as Escherichia coli (Harned et al., 1951). Mycobacterium smegmatis and Candida albicans are inhibited at 2 µg/ml, and fungi are inhibited at somewhat higher concentrations. The antibiotic is not active against bacteriophages at 500 µg/ml (Hall et al., 1951). The LD50 (intraperitoneally) is 2.5 mg/kg in mice.

Keywords

ATPase Activity Krebs Cycle Antibiotic Concentration Mycobacterium Smegmatis Intact Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • Paul D. Shaw

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