Antibiotics pp 611-612 | Cite as

Usnic Acid

  • Paul D. Shaw


Usnic acid (usninic acid) is an antibiotic produced by many species of lichens (Stoll et al., 1947). Its chemistry was studied by Widman (1902), and the following structure was proposed by Schopf and Ross (1938, 1947). Usnic acid was synthesized by Barton et al. (1956).


Electron Transport System Inorganic Phosphate Uptake Usnic Acid Phosphoryl Transfer Corynebacterium Diphtheriae 
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  1. Barton, D. H. R., A. M. Deflorin, and O. E. Edwards: The synthesis of usnic acid. J. Chem. Soc. 1956, 530.Google Scholar
  2. Castle, H., and F. Kuusch: The production of usnic, didymic and rhodocladonic acids by the fungal component of the lichen Cladonia cristatella. Arch. Biochem. 23, 158 (1949).PubMedGoogle Scholar
  3. Creaser, E. H.: The induced (adaptive) biosynthesis of ß-galactosidase in Staphylococcus aureus. J. Gen. Microbiol. 12, 288 (1955).PubMedCrossRefGoogle Scholar
  4. Johnson, R. B., G. Feldott, and H. A. Lardy: The mode of action of the antibiotic usnic acid. Arch. Biochem. (now Arch. Biochem. Biophys.) 28, 317 (1950).Google Scholar
  5. Lardy, H. A., J. L. Connelly, and D. Johnson: Antibiotics as tools for metabolic studies. II. Inhibition of phosphoryl transfer in mitochondria by oligomycin and aurovertin. Biochemistry 3, 1961 (1964).PubMedCrossRefGoogle Scholar
  6. Naito, M., R. Watanabe, R. Kitagawa, K. Iba, S. Imai, F. Fujikawa, S Nakazawa, Y. Yagi, J. Yagi, and M. Nishimoto: Effect of some compounds on tubercle bacilli in vitro. Viii. Antibacterial activity of several hydrazone compounds in vitro. Yakugaku Zasshi 77, 1251 (1957) [Chem. Abstr. 52, 4016a (1958)].Google Scholar
  7. Savich, V. P., M. A. Litvinov, and E. N. Moiseeva: An antibiotic from lichens as a medicinal product. Planta Med. 8, 191 (1960).CrossRefGoogle Scholar
  8. Schopf, C., and F. Ross: Die Konstitution der Usninsäure. Naturwissenschaften 26, 772 (1938).CrossRefGoogle Scholar
  9. Schopf, C., and F. Ross: Die Konstitution der Usninsäure. II. Justus Liebigs Ann. Chem. 1 (1941).Google Scholar
  10. Stoll, A., A. Brack and J. Reng: Die antibakterielle Wirkung der Usninsäure auf Mykobakterien and andere Mikroorganismen. Experientia 3, 115 (1947).PubMedCrossRefGoogle Scholar
  11. Tomaselli, R.: New usnic acid derivative used therapeutically. Farmaco (Pavia), Ed. pract. Ed. sci. 12, 137 (1957) [Chem. Abstr. 51, 9091 c (1957)].Google Scholar
  12. Virtanen, O. E., and O. E. Kilpio: Fungistatic activity of an usnic acid preparation with the trade name Usno. Suomen Kemistilehti 30, 8 (1957) [Chem. Abstr. 51, 10743e(1957)].Google Scholar
  13. Virtanen, O. E.: Derivatives of usnic acid with the most important tuberculostatic agents. Suomen Kemistilehti B 28, 125 (1955).Google Scholar
  14. Widman, D.: Zur Kenntnis Usninsäure. Justus Liebigs Ann. Chem. 324, 139 (1902).CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1967

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  • Paul D. Shaw

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