In addition to certain normal cellular metabolites that exert control over the biosynthesis of nucleic acids, a large number of substances synthesized chemically or obtained from natural sources have now been demonstrated to interfere with the ultimate formation of these macro-molecules. These inhibitors, which are structurally related to purines, pyrimidines and amino acids, have been found to antagonize the metabolism of a corresponding normal substrate. Furthermore, the modes of action of some of these antimetabolites have been elucidated. This review pertains to hadacidin, a structural analogue of L-aspartic acid, isolated from the fermentation fluid of Penicillium frequentans and subsequently found to inhibit the biosynthesis de novo of adenylic acid.
KeywordsAdenylic Acid Ehrlich Ascites Tumor Cell Propionate Sodium Preliminary Clinical Trial Ehrlich Ascites Cell
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