Advertisement

Antibiotics pp 415-426 | Cite as

Rifamycins

  • Laura Frontali
  • Giorgio Tecce
Chapter

Abstract

Rifamycins1 are a group of closely related antibiotics produced by a Streptomyces strain first isolated in “Lepetit Research Laboratories” (Milan, Italy) from a soil sample collected near St. Raphael (France). The strain was cultured in shakeflasks and the fermentations broths showed high activity against grampositive bacteria and Mycobacterium tuberculosis (Sensi et al., 1959). A limited activity against gramnegative bacteria was also present. A detailed description of this strain was reported by Margalith and Beretta (1960); its cultural and biochemical characteritics led these Authors to conclude that this strain constitutes a new species which was named Streptomyces mediterranei.

Keywords

Bacillus Subtilis Neisseria Gonorrhoeae Magnesium Acetate Subtilis Cell Brucella Melitensis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Basilico, E., e C. Grassi: Attività antitubercolare della rifamicina SV nella monocitocultura. Giorn. ital. tuberc. 16, 66 (1962).Google Scholar
  2. Bergamini, N., and G. Fowst: Rifamycin SV: a review. Arzneimittel-Forsch. 15, 1951 (1965).Google Scholar
  3. Baufant, M., W. Fedeli, G. Giacomello, and A. Vaciago: X ray determination of the structure of rifamycin. Accad. naz. Lincei, R. C. Classe Sci. fis. mat. nat. 36, 113 (1964).Google Scholar
  4. Calvori, C., L. Frontali, L. Leoni, and G. Tecce: Effect of rifamycin on protein synthesis. Nature 207, 417 (1965).PubMedCrossRefGoogle Scholar
  5. Calvori, C., L. Frontali, L. Leoni, and G. Tecce: In preparation (1966).Google Scholar
  6. Frontali, L., L. Leoni, and G. Tecce: Action of rifamycin on incorporation of aminoacids into proteins in cell-free systems from B. subtilis. Nature 203, 84 (1964).PubMedCrossRefGoogle Scholar
  7. Füresz, S., and R. ScoTti: Rifomycin. IV. Some laboratory and clinical experiences with rifomycin B. Antibiotics Ann. 1959/60, 285 (1960).Google Scholar
  8. Füresz, S., and R. Scotti: Rifomycin. XX. Further studies on rifomycin SV: in vitro activity, absorption and elimination in man. Farmaco, Ed. sci. 16, 262 (1961).Google Scholar
  9. Füresz, S., and M. T. Timbal: Antibacterial activity of rifamycins. Internat. Symposium on Rifamycins, Milan 1963, Chemotherapia 7, 200 (1963).CrossRefGoogle Scholar
  10. Ginoulhiac, E., and U. Bonomi: VI Int. Congr. Biochem., New York City 1964.Google Scholar
  11. Graziosi, F.: Metodo per la coltura continua di batteri in turbidostato. Giorn. microbiol. 1, 491 (1956).Google Scholar
  12. Leoni, L., e G. Tecce: Azione della rifamicina SV sulle reazioni della sintesi proteica. Internat. Symposium on Rifamycins, Milan 1963. Chemoterapia 7, 194.Google Scholar
  13. Maffii, G., P. Schiatti, G. Bianchi, and M. G. Serralunga: Rifomycin. XVIII. Pharmacological studies with rifomycin SV. Changes in respiratory activity of mitochondria induced by rifomycins. Farmaco, Ed. sci. 16, 235 (1961).Google Scholar
  14. Maggi, N., G. G. Gallo e P. Sensi: Proprietà chimiche e chimico fisiche della dietilammide della rifamicina B. Farmaco 20, 147 (1965).Google Scholar
  15. Margalith, P., and G. Beretta: Rifomycin. XI. Taxonomic study on Streptomyces mediterranei nova species. Mycopathol. et Mycol. Appl. 13, 321 (1960).CrossRefGoogle Scholar
  16. Margalith, P., and H. Pagani: Rifomycin. XIV. Production of rifomycin B. Appl. Microbiol. 9, 325 (1961).PubMedGoogle Scholar
  17. Marmur, J.: A procedure for the isolation of DNA from microorganisms. J. Mol. Biol. 3, 208 (1961).CrossRefGoogle Scholar
  18. Matthaei, H. J., and M. W. Nirenberg: Characteristics and stabilization of DNAase sensitive protein synthesis in E. coli extracts. Proc. Nat. Acad. Sci. U.S. 47, 1580 (1961).CrossRefGoogle Scholar
  19. Nitti, V., R. Virgilio, e A. Minni: Attività della rifomicina SV sui micobatteri in vitro. A.ch. tisiol. mal. app. respirat. (Naples) 16, 1023 (1961).Google Scholar
  20. Ofengand, J., and R. Haselkorn: Viral RNA dependent incorporation of amino acids into protein by cell-free extracts of E. coli. Biochem. Biophys. Research Comm. 6, 469 (1962).CrossRefGoogle Scholar
  21. Oppolzer, W., V. Prelog u. P. Sensi: Konstitution des Rifamycins B and verwandter Rifamycine. Experientia 20, 336 (1964).PubMedCrossRefGoogle Scholar
  22. Pallanza, R., S. Füresz, M. T. Timbal, and G. Carniti: In vitro bacteriological studies on rifamycin B diethylamide (rifamide). (In the press 1965.)Google Scholar
  23. Prelog, V.: Über die Konstitution der Rifamycine. Internat. Symposium on Rifamycins. Milan, June 5 6. Chemotherapia 7, 133 (1963a).CrossRefGoogle Scholar
  24. Prelog, V.: Constitution of rifamycins. Symposium on Chemistry and Biochemistry of Fungi and Yeast, Dublin, July 18–20, p. 551. London: Butterworths 1963 (1963c).Google Scholar
  25. Prelog, V.: Constitution of rifamycins. Pure Appl. Chem. 7, 551 (1963b).CrossRefGoogle Scholar
  26. Sensi, P.: A family of new antibiotics, rifamycins. Res. Progr. Org. Biol. Med. Chem. 1, 337 (1964).Google Scholar
  27. Sensi, P., R. Ballotta, and A. M. Greco: Rifomycin. V. Rifomycin O, a new antibiotic of the rifomycin family. Farmaco, Ed. sci. 15, 228 (1960c).Google Scholar
  28. Sensi, P., R. Ballotta, and G. G. Gallo: Rifomycin. XV. Activation of rifomycin B and rifomycin O. Production and properties of rifomycin S and rifomycin SV. Farmaco, Ed. sci. 16, 165 (1961).Google Scholar
  29. Sensi, P., A. M. Greco, and R. Ballotta: Rifomycins. I. Isolation and properties of rifomycin B and rifomycin complex. Antibiotics Ann. 1959/60, 262 (1960a).Google Scholar
  30. Sensi, P., N. Maggi, R. Ballotta, S. Füresz, R. Pallanza, and V. Arioli: Rifamycins. XXXV. Amides and hydrazides of rifamycin B. J. Medicinal Chem. 7, 596 (1962).CrossRefGoogle Scholar
  31. Sensi, P., P. Margalith, and M. T. Timbal: Rifomycin, a new antibiotic. Preliminary report. Farmaco, Ed. sci. 14, 146 (1959).Google Scholar
  32. Sensi, P., M. T. Timbal, and G. Maffii: Rifomycin. IX. Two new antibiotics of rifomycin family: Rifomycin S and rifomycin SV. Preliminary report. Experientia 16, 412 (1960b).PubMedCrossRefGoogle Scholar
  33. Tissières, A., D. Schlessinger, and F. Gros: Amino acid incorporation into proteins by E. coli ribosomes. Proc. Natl. Acad. Sci. U.S. 46, 1450 (1960).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • Laura Frontali
  • Giorgio Tecce

There are no affiliations available

Personalised recommendations