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Antibiotics pp 410-414 | Cite as

Sparsomycin

  • Libor Slechta

Abstract

Sparsomycin is one of the antibiotics produced by Streptomyces sparsogenes var. sparsogenes (Owen, Dietz and Camiener, 1962). It has been isolated as crystalline material from the culture filtrates and has the molecular formula C31H21N3O6S2 (Argoudelis and Herr, 1962) but its structure is not yet known.

Keywords

Culture Filtrate Brain Heart Infusion Broth Sucrose Density Gradient Centrifugation Minute Exposure Release Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Argoudelis, A. D., and R. R. Herr: Sparsomycin, a new antitumor antibiotic. II. Isolation and characterization. Antimicrobial Agents and Chemotherapy, p. 780 (1962).Google Scholar
  2. Biswas, B. B., M. Edmonds, and R. Abrams: Methylation of the purines of soluble RNA with methyl labeled methionine. Biochem. Biophys. Research Commun. 6, 146 (1961).CrossRefGoogle Scholar
  3. Colombo, B., L. Felicetti, and C. Bagliono: Inhibition of protein synthesis by antibiotics in reticulocytes. Biochim. et Biophys. Acta (in press) (1965).Google Scholar
  4. Owen, S. P., A. Dietz, and G. W. Camiener: SparSomycin, a new antitumor antibiotic. I. Discovery and biological properties. Antimicrobial Agents and Chemotherapy, p. 772 (1962).Google Scholar
  5. Pittillo, R. F., M. Lucas, C. Woolley, R. T. Blackwell, and C. Moncrief: Sparsomycin modification of the lethal action of ionizing irradiation on Eschei’ichia coli. Nature 205, 773 (1965).PubMedCrossRefGoogle Scholar
  6. Slechta, L.: Mode of action of sparsomycin in E. coli B. Antimicrobial Agents and Chemotherapy 326 (1965).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • Libor Slechta

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