Antibiotics pp 366-377 | Cite as

Macrolide antibiotics — Spiramycin, Carbomycin, Angolamycin, Methymycin and Lancamycin

  • D. Vazquez


The term macrolide has been applied to members of a group of structurally related antibiotics produced by species of streptomyces. All macrolide antibiotics (Woodward, 1957) contain a large lactone ring (aglycone of 12 to 22 atoms) which contain few double bonds and no nitrogen atoms; they have one or more sugars which can be amino sugars, non-nitrogenous sugars or both. In the widest sense however, the term macrolide has been ascribed to all the antibiotics containing a large lactone ring; in this sense the polyene antibiotic and antibiotics of streptogramin A and streptogramin B groups can be also termed macrolides. This article will be restricted to the “classical” macrolides of Woodward (1957) and related compounds discovered after 1957.


Inhibit Protein Synthesis Amino Sugar Macrolide Antibiotic Bacillus Megaterium Cross Resistance 
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© Springer-Verlag Berlin Heidelberg 1967

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  • D. Vazquez

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