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Antibiotics pp 190-210 | Cite as

Daunomycin and Related Antibiotics

  • A. Di Marco

Abstract

Daunomycin (Da) is a metabolite of Streptomyces peucetius (Grein et al., 1963) which strongly inhibits a variety of experimental tumors (Di Marco et al., 1964b). The antibiotic substance is a glycoside (Hydrochloride: C27H29NO10 · HC1) which by acid hydrolysis yields an aglycone, daunomycinone (Arcamone et al., 1964b) and a new aminosugar, daunosamine (Arcamone et al., 1964a). Dubost et al. (1963) have also described an antibiotic, rubidomycin, whose physicochemical characteristics correspond to those of daunomycin. Daunomycin is closely related to the anthracyclines. Following Brockmann’s suggestion (1963), those antibiotics that contained a tetrahydrotetracenquinone chromophore linked to a sugar should all be included in the anthracycline group. The chromophores of such antibiotics have different substituents on the nucleus (Fig. 1 and Table 1).

Keywords

HeLa Cell Mitotic Index Sedimentation Coefficient Bone Marrow Aplasia Ehrlich Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1967

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  • A. Di Marco

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