Pluramycin A, obtained from the culture broth of Streptomyces pluricolorescens by Maeda et al. (1956), is a basic antibiotic. It forms orange needle crystals which are yellow in acid and purple in alkali. The molecular formula, C20H25O5N, was suggested and confirmed by S. Nakamura (personal communications). Another antibiotic, designated pluramycin B, was isolated from the same culture filtrate in a crude form. Both pluramycins A and B inhibit growth of bacteria and tumor cells. Ogawara et al. (1966) observed that a macromolecular antitumor substance (molecular weight 30,000–60,000) is also produced by the same organism. It consists of a pluramycin-like prosthetic group and a glycoprotein, and is designated plurallin.
KeywordsMinimal Inhibitory Concentration Minimal Inhibitory Concen Shigella Dysenteriae Crude Form Ehrlich Carcinoma
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