Advertisement

Zusammenfassung

1928 veröffentlichte F. Duran-Reynals (23) die Wirkung eines aus normalem Tierhoden extrahierten Stoffes auf die Infektion von Kaninchen mit Neuro-vaccine. Diese Wirkung bestand in einer gesteigerten Ausbreitung des infektiösen Materials am Orte der Injektion dieses Stoffes. Da sich durch gleichzeitige Injektion von Farbstoffen mit diesem Hodenextraktstoff leicht nachweisen läßt, daß der Farbstoff weiter ausgebreitet wird, seine Diffusion gewissermaßen erhöht wird, oder daß die Permeabilität des Hautgewebes vermehrt wird, so wurde dieser Stoff in der Folgezeit als Diffusionsfaktor oder Permeabilitätsfaktor bezeichnet. Ledingham und Barrat (64) schlugen vor, solange es nicht möglich ist, diesen Stoff seiner Natur nach sachlich zu bezeichnen, ihn Reynausschen Faktor (R. F.) zu nennen, und wir wollen im folgenden der Einfachheit halber bei dieser Bezeichnung: R. F. bleiben. Es ist seitdem über diesen R. F. ein erhebliches Schrifttum entstanden, das bisher von Douglas McClean (74) und von Duran-Reynals (32) eine zusammenfassende Darstellung erfuhr. Da dem R. F. ein erhebliches biologisches Interesse zukommt, andererseits die bisherigen Arbeiten in Deutschland keine Beachtung fanden, so dürfte ein zusammenfassendes Referat über den Reynalsschen Diffusionsfaktor angebracht sein.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Astbury, W. T.: Zit. nach D. McClean (1936).Google Scholar
  2. 2.
    Aylward, Francis X.: Chemical nature of the Reynals spreading factor from mammalian testicle. Proc. Soc. exper. Biol. a. Med. 36, 477–481 (1937).Google Scholar
  3. 3.
    Behring, O. v.: Ein Beitrag zur Kenntnis des Reynalsschen Diffusionsfaktors. Z. Immun.forsch. 1941 (im Druck).Google Scholar
  4. 4.
    Bier, O.: Influence de l’extrait testiculaire sur le phénomène de Shwartzman. C. r. Soc. Biol. Paris 112, 407–410 (1933).Google Scholar
  5. 5.
    Bier, O. et N. Planet: Sur la présence d’un facteur qui augmente la permeabilité capillaire dans les extraits de peau normale. C. r. Soc. Biol. Paris 129, 65–67 (1938).Google Scholar
  6. 6.
    Bier, O. et N. Planet: Sur la permeabilité capillaire dans le phénomène de Shwartzman. C. r. Soc. Biol. Paris 129, 68–70 (1938).Google Scholar
  7. 7.
    Boyland, E. and D. McClean: A factor in malignant tissues which increases the permeability of the dermis. J. of Path. 41, 553–565 (1935).Google Scholar
  8. 8.
    Burnet, F. M.: Shwartzman’s phenomenon of local skin reactivity to bacterial products. J. of Path. 34, 45–60 (1931).Google Scholar
  9. 9.
    Caporale, G.: L’influence du „facteur R “sur l’implantation et la généralisation du B. tuberculeux aviaire. Boll. Soc. internaz. Microbiol., sez. ital. 11, 144–157 (1939). Ref. Zbl. Bakter. 137, 222.Google Scholar
  10. 10.
    Castellani, G. T.: Ulteriori ricerche sul fattore di diffusione dei veleni degli ofidi. Specifita delia neutralizzazione coi sieri immuni. Boll. Ist. sieroter, milan. 19, 332–337 (1940).Google Scholar
  11. 11.
    Chain, E. and E. S. Duthie: A Mucolytic Enzyme in testis extracts. Nature (Lond.) 144, 977 (1939).Google Scholar
  12. 12.
    Chrestensen, J. F.: Die Reynalsschen Faktoren im Harn. Hosp.tid. (dän.) 8, 572 (1938). Ref. Kongreßzbl. inn. Med. 97, 2.Google Scholar
  13. 13.
    Chrestensen, J. F.: A spreading factor from Serum. J. of Path. 48, 287–290 (1939).Google Scholar
  14. 14.
    Claude, A.: Spreading properties of azo proteins in the dermis. Science (N.Y.) 78, 151 (1933).Google Scholar
  15. 15.
    Claude, A.: J. of exper. Med. 62, 229–244 (1935).Google Scholar
  16. 16.
    Claude, A.: Spreading properties of leech extracts and the formation of lymph. J. exper. Med. 66, 353–366 (1937).Google Scholar
  17. 17.
    Claude, A.: The enhancing effect of azo proteins on the lesions produced by vaccine virus, the Shope fibroma virus and the agent transmitting chicken tumor I. J. of exper. Med. 69, 641–648 (1939).Google Scholar
  18. 18.
    Claude, A.: Spreading properties and mucolytic activity of leech extracts. Proc. Soc. exper. Biol. a. Med. 43, 684 (1940).Google Scholar
  19. 19.
    Claude, A. and F. Duran-Reynals: On the existence of a factor increasing tissue permeability in organs other than testicle. J. of exper. Med. 60, 457–462 (1934).Google Scholar
  20. 20.
    Claude, A. and F. Duran-Reynals: Chemical properties of the purified spreading factor from testicle. J. of exper. Med. 65, 661–670 (1937).Google Scholar
  21. 21.
    Cosentino, G.: Das Diffusionsphänomen der Hodenextrakte (Faktor R) im Granulationsgewebe. Pathologica (Genova) 32, 26–33 (1940).Google Scholar
  22. 22.
    Dawson, M. H.: Variations in the pneumococcus. J. of Path. 39, 323–344 (1934).Google Scholar
  23. 23.
    Duran-Reynals, F.: Exaltation de l’activité du virus vaccinal par des extraits de certains organes. C. r. Soc. Biol. Paris 99, 6 (1928).Google Scholar
  24. 24.
    Duran-Reynals, F.: The Effect of extracts of certain organs from normal and immunized animals. On the infective power of vaccine virus. J. of exper. Med. 50, 327–340 (1929).Google Scholar
  25. 25.
    Duran-Reynals, F.: The effect of testicle extract and of normal Serum on a transplantable epithelial tumor of the rabbit. J. of exper. Med. 54, 493–498 (1931).Google Scholar
  26. 26.
    Duran-Reynals, F.: The effect of antitesticular Serum on the enhancement value of testicle extract. J. of exper. Med. 55, 703–712 (1932).Google Scholar
  27. 27.
    Duran-Reynals, F.: Studies on a certain spreading factor existing in bacteria and its significance for bacterial invasiveness. J. of exper. Med. 58, 161–181 (1933)Google Scholar
  28. 28.
    Duran-Reynals, F.: Further studies on the influence of testicle extract upon the effect of toxins, bacteria and viruses and on the Shwartzman- and Arthusphenomena. J. of exper. Med. 58, 451–463 (1933).Google Scholar
  29. 29.
    Duran-Reynals, F.: Reaction of spontaneous mouse carcinomas to blood-carried bacterial toxins. Proc. Soc. exper. Biol. a, Med. 32, 1517–1521 (1935).Google Scholar
  30. 30.
    Duran-Reynals, F.: The extent of local dispersion of infectious agents as a factor of resistance to infection. J. of exper. Med. 61, 617–642 (1935).Google Scholar
  31. 31.
    Duran-Reynals, F.: The invasion of the body by animal poisons. Science (N.Y.) 83, 286, 287 (1936).Google Scholar
  32. 32.
    Duran-Reynals, F.: Les „facteures de diffusion” et leur signification. Ann. Inst. Pasteur. 57, 597–621 (1936).Google Scholar
  33. 33.
    Duran-Reynals, F.: A spreading factor in certain snake venoms and its relation to their mode of action. J. of exper. Med. 69, 69–81 (1939).Google Scholar
  34. 34.
    Duran-Reynals, F. and A. Claude: Further experiments on the effect of testicle extract on the agent of chicken tumor I. Proc. Soc. exper. Biol. a. Med. 32, 67, 68 (1934).Google Scholar
  35. 35.
    Duran-Reynals, F. and F. W. Stewart: The action of tumor extracts on the spread of experimental vaccinia of the rabbit. Amer. J. Canc. 15, 2790–2797 (1931).Google Scholar
  36. 36.
    Duran-Reynals, F. et J. Suner Pi: Exaltation de l’activité du Staphylocoque par les extraits testi-culaires. C. r. Soc. Biol. Paris 99, 1908 (1928).Google Scholar
  37. 37.
    Evans, M. G. u. J. Madinaveitta: Der Wirkungsmechanismus diffusionsbegünstigen-der Faktoren. Biochemic. J. 34, 613–620 (1940). Ref. Chem. Zbl. 1940II, 3660.Google Scholar
  38. 38.
    Favilli, G.: The effect of testicle extract on red blood cells in vitro. J. of exper. Med. 54, 197–206 (1931).Google Scholar
  39. 39.
    Favilli, G.: The influence of some organ extracts on the permeability to water of seaurchin eggs (Arbacia punctata). J. cellul. a. comp. Physiol. 2, 1–10 (1932).Google Scholar
  40. 40.
    Favilli, G.: Die Wirkung von Calciumsalzen und Urethan auf die Vaccineinfektion beim Kaninchen. Boll. Soc. internaz. Microbiol., sez. ital. 5, 115–119 (1933). – Suüa esistenza di fattori di origine istogena capaci di modificare la permeabilità dei tessuti. VI. Azione antagonistica dell’estratto testicolare e di alcuni sali di calcio e derivati dell’acido carbammico (uretani). Contributo allo studio del meccanismo della immunità locale. Sperimentale 87, 451–469 (1933).Google Scholar
  41. 41.
    Favilli, G.: Proprietà mucinolitiche dei fattori diffusori. Boll. 1st. sieroter. milan. 19, 481–500 (1940).Google Scholar
  42. 42.
    Favilli, G. and D. McClean: The influence of testicular extracts upon the fragility of red blood cells and upon the dispersion of Indian ink particles in the dermis. J. of Path. 38, 153–165 (1934).Google Scholar
  43. 43.
    Favilli, G. and D. McClean: The influence of tissue permeability on local immunity. J. of Path. 45, 661–680 (1937).Google Scholar
  44. 44.
    Fellowes, O.N. u. P. Hudson: Der Duran-Reynals Faktor in den Organen erwachsener und fetaler Meerschweinchen und sein Einfluß auf das Vaccinevirus. Amer. J. Hyg. 30, 11–20 (1939).Google Scholar
  45. 45.
    Friedheim: Sind die Lymphdrüsen primäre Blutfilter? Eine morphologische und experimentelle Untersuchung. Frankf. Z. Path. 35, 549–573 (1927).Google Scholar
  46. 46.
    Gaetani, G. F. de: Boll. Soc. Biol. sper. 7, 8 (1932).Google Scholar
  47. 47.
    Glenny, A. T., Llewellyn-Jones and J. M. Mason: The intracutaneous method of testing the toxins and antitoxins of the gas gangrene organisms. J. of Path. 34, 201–211 (1931).Google Scholar
  48. 48.
    Goodner, K.: The development and localization of the dermal pneumococcic lesion in the rabbit. J. of exper. Med. 54, 847–858 (1931).Google Scholar
  49. 49.
    Goodner, K.: The effect of pneumococcus autolysates upon pneumococcus dermal infection in the rabbit. J. of exper. Med. 58, 153–160 (1933).Google Scholar
  50. 50.
    Gratia, A. et R. Linz: Les Phénomènes de Sanarelli et de Shwartzman ou l’allergie hémorragique. Ann. Inst. Pasteur 49, 131–185 (1932).Google Scholar
  51. 51.
    Hegemann, Gerd: Über Streptokokkengifte. Arch. f. Hyg. 121, 331–348 (1939).Google Scholar
  52. 52.
    Hobby, Gl. L., M. H. Dawson, K. Meyer and E. Chaffee: The relationship between spreading factor and hyaluronidase. J. of exper. Med. 73, 109–123 (1941).Google Scholar
  53. 53.
    Hobson, A. D.: The effect of fertilisation on the permeability to water and on certain other properties of the surface of the egg of psammechinus miliaris. J. of exper. Biol. 9, 69–92 (1932).Google Scholar
  54. 54.
    Hoffman, D. C.: The effect of testicular extract on filterable viruses. J. of exper. Med. 53, 43–50 (1931).Google Scholar
  55. 55.
    Hoffman, D. C. and F. Duran-Reynals: The influence of testicle extract on the intradermal spread of injected fluids and particles. J. of exper. Med. 53, 387–398 (1931).Google Scholar
  56. 56.
    Hoffman, D. C. and F. Duran-Reynals: The mechanism of enhancement of infections by testicle extract. Science (N.Y.) 72, 508 (1930).Google Scholar
  57. 57.
    Hoffman, D. C., F. Parker and T. T. Walker: The effect of testicle extract on the Rous Sarcoma. Amer. J. Path. 7, 523–532 (1931).PubMedPubMedCentralGoogle Scholar
  58. 58.
    Howitt, B. F.: Certain properties of the virus of equine encephalomyelitis. J. inf. Dis. 55, 138 (1934).Google Scholar
  59. 59.
    Inouyé, Z.: De la receptivité de la muqueuse intestinale ou cours de l’immunisation contre le vibrion cholérique. Ann. Inst. Pasteur 42, 394–402 (1928).Google Scholar
  60. 60.
    Jorpes, E., H. Holmgren u. O. Wilander: Über das Vorkommen von Heparin in den Gefäßwänden und in den Augen. Ein Beitrag zur Physiologie der Ehrlichschen Mastzellen. Z. mikrosk.-anat. Forschg 42, 279–301 (1937).Google Scholar
  61. 61.
    Kabat, E. A.: A polysaccharide in tumors due to a virus of leucosis and sarcoma of fowls. J. of biol. Chem. 130, 143–147 (1939).Google Scholar
  62. 62.
    Kendall, F. E., M. Heidelberger and M. H. Dawson: A serologically inactive polysaccharide elaborated by mucoid strains of group A hemolytic streptococcus. J. of biol. Chem. 118, 61–69 (1938).Google Scholar
  63. 63.
    Kraut, H., E. K. Frey u. E. Werle: Über die Inaktivierung des Kallikreins. Z. physiol. Chem. 192, 1–21 (1930).Google Scholar
  64. 64.
    Ledingham, J. C. G. and M. M. Barratt: On the visceral lesions that may accompany experimental vaccinia in rabbits. Lancet 2, 515–519 (1929).Google Scholar
  65. 65.
    Letterer, E.: Über epitheliale und mesodermale Schleimbildung. Leipzig: S. Hirzel 1932.Google Scholar
  66. 66.
    Lücke, B., H. K. Hartline and M. McCutcheon: Further studies of the kinetics of osmosis in living cells. J. gen. Physiol. 14, 405–419 (1931).PubMedPubMedCentralGoogle Scholar
  67. 67.
    Lurie, M. B.: Nature of inherited natural resistance to tuberculosis. Proc. Soc. exper. Biol. a. Med. 39, 181–187 (1938).Google Scholar
  68. 68.
    Lurie, M. B. and P. Zappasodi: Relative spread of particulate and diffusible substances in the skin of male and female rabbits. Proc. Soc. exper. Biol. a. Med. 42, 741–744 (1939).Google Scholar
  69. 69.
    Madinaveitia, Juan: Studies on diffusing factor III. Biochemic. J. 33, 1470–1477 (1939).Google Scholar
  70. 70.
    Madinaveitia, Juan and T. H. H. Quibell: Studies on diffusing factor VI. The action of testicular extracts on the viscosity of vitreous humor preparations. Biochemic. J. 34, 625–631 (1940).Google Scholar
  71. 71.
    Mannozzi-Torini, M.: Esperimente di separazione del fattore diffusore dell’estratto testicolare mediante l’adsorbimento. Arch. di Sci. biol. 25, 473–486 (1939). Ref. Chem. Zbl. 1940 II, 1889.Google Scholar
  72. 72.
    McClean, D.: The influence of testicular extract on dermal permeabihty and the resposne to vaccine virus. J. of Path. 33, 1045–1070 (1930).Google Scholar
  73. 73.
    McClean, D.: J. of Path. 34, 459 (1931).Google Scholar
  74. 74.
    McClean, D.: The Influence on tissue permeability of a substance extracted from mammalian testes. Biol. Rev. Cambridge, philos. Soc. 8, 345–356 (1933).Google Scholar
  75. 75.
    McClean, D.: A Factor in culture filtrates of certain pathogenic bacteria which increases the permeability of the tissues. J. of Path. 42, 477–512 (1936).Google Scholar
  76. 76.
    McClean, D. and C. W. Hale: Mucinase and tissue permeability. Nature (Lond.) 145, 867, 868(1940).Google Scholar
  77. 77.
    McClean, D. and W. T. J. Morgan: The influence of purified testicular extract upon the rate of absorption of antitoxin. J. of Path. 36, 193, 194 (1933).Google Scholar
  78. 78.
    McClean, D. W. T. J. Morgan and G. Favilli: Further observations on the influence of testicular extract on the rate of absorption of Diphtheria antitoxine and on the response to immunization with toxoid. J. of Path. 38, 253–258 (1934).Google Scholar
  79. 79.
    McDowell Hammon, W.: Attempts to propagate poliomyelitis virus through serial passage in cotton rats by „spreading” of Duran-Reynals. Proc. Soc. exper. Biol. a. Med. 45, 124–126 (1940).Google Scholar
  80. 80.
    Menkin, V.: Studies in inflammation. I. Fixation of vital dyes in inflamed areas. J. of exper. Med. 50, 171–180 (1929).Google Scholar
  81. 81.
    Menkin, V. and M. F. Menkin: II. A measure of the permeability of capillaries in an inflamed area. J. of exper. Med. 51, 285–293 (1930).Google Scholar
  82. 82.
    Meyer, K.: The chemistry and biology of mucopolysaccharides and glycoproteins. Cold Spring Harbor Symp. on quantit. Biol. 6, 91–102 (1938).Google Scholar
  83. 83.
    Meyer, K. and E. Chaffee: Hyaluronic acid in pleura fluid associated with malignant tumor involving pleura and peritoneum. J. of biol. Chem. 133, 83–91 (1940).Google Scholar
  84. 84.
    Meyer, K. and E. Chaffee: Proc. Soc. exper. Biol. a. Med. 42, 797–800 (1939).Google Scholar
  85. 85.
    Meyer, K. and E. Chaffee: Mucopolysaccharide acid of cornea and possible relation to the „spreading factor”. Proc. Soc. exper. Biol. a. Med. 43, 487 (1940).Google Scholar
  86. 86.
    Meyer, K. R. Dubos and E. M. Smyth: The hydrolysis of the polysaccharide acids of vitreous humor of umbilical cord and of Streptococcus by the autolytic enzyme of pneumo- coccus. J. of biol. Chem. 118, 71–78 (1937).Google Scholar
  87. 87.
    Meyer, K. Gl. L. Hobby, E. Chaffee and M. H. Dawson: Relationship between „spreading Faktor” and Hyaluronidase. Proc. Soc. exper. Biol. a. Med. 44, 294–296 (1940).Google Scholar
  88. 88.
    Meyer, K. Gl. L. Hobby, E. Chaffee and M. H. Dawson: The hydrolysis of hyaluronic acid by bacterial enzymes. J. of exper. Med. 71, 137–146 (1940).Google Scholar
  89. 89.
    Meyer, K. Gl. and J. W. Palmer: The polysaccharide of the vitreous humor. J. of biol. Chem. 107, 629–634 (1934).Google Scholar
  90. 90.
    Meyer, K. Gl. and J. W. Palmer: On Glycoproteins. II.: The polysaccharides of vitreous humor and of umbilical cord. J. biol. of Chem. 114, 689–703 (1936).Google Scholar
  91. 91.
    Meyer, K. Gl., J. W. Palmer and E.M. Smyth: On Glycoproteins V. Protein complexes of chondroitin- sulfuric acid. J. of biol. Chem. 119, 501–506 (1937).Google Scholar
  92. 92.
    Meyer, K. Gl. and E. M. Smyth: On Glycoproteins VT.: The preparation of chondroitinsulfuric acid. J. of biol. Chem. 119, 507–510 (1937).Google Scholar
  93. 93.
    Meyer, K. Gl. and E. M. Smyth: he isolation of a mucoitin disulfuric acid from gastric mucin. J. of biol. Chem. 123 (1938).12Google Scholar
  94. 94.
    Meyer, K. Gl., E. M. Smyth and M. H. Dawson: The isolation of mucopolysaccharide from synovial fluid. J. of biol. Chem. 128, 319–327 (1939).Google Scholar
  95. 95.
    Meyer, K. Gl., E. M. Smyth and J. W. Palmer: On Glycoproteins III. The polysaccharides from pig gastric mucosa. J. of biol. Chem. 119, 73–83 (1937).Google Scholar
  96. 96.
    Meyer, K. Gl., E. M. Smyth and E. Gallardo: On the nature of the ocular fluids. II. The hexosamine contents. Amer. J. Ophthalm, III. s. 21, 1083–1090 (1938).Google Scholar
  97. 97.
    Morgan, W. T. J. and D. McClean: Purification of a substance present in the testicle which increases tissue permeability. J. Soc. chem. Ind. (Chem. Industr. Sect.) 51, 44, 912 (1932). 395Google Scholar
  98. 98.
    Xagell, H. u. J. Langhans: Über die Granulations- und epithelisierungsfördemde Wirkung des Hodenextraktes. Münch. med. Wschr. 1930 I, 450, 451.Google Scholar
  99. 99.
    Parsons, R. J. and Ph. D. McMaster: Normal and pathological factors influencing the spread of a vital dye in the connective tissue. J. of exper. Med. 68, 869–890 (1938).Google Scholar
  100. 100.
    Pijoan, M.: The action of testicle-, kidney- and spleen extracts on the infective power of bacteria. J. of exper. Med. 53, 37–42 (1931).Google Scholar
  101. 101.
    Radici: Boll. Ist. sieroter. milan. 18, 316 (1939).Google Scholar
  102. 102.
    Robertson, W. van B., M. W. Ropes and W. Bauer: Mucinase: a bacterial encyme, which hvdrolvzes synovial fluid mucin and other mucins. J. of biol. Chem. 133, 261 bis 276 (1940).Google Scholar
  103. 103.
    Romano, M.: Pathologica (Genova) 31, 253 (1939). Ref. Chem. Zbl. 1939 II, 1906.Google Scholar
  104. 104.
    Romanoff, A.: The effect of testicular extract (Reynals spreading factor) upon human skin. J. Allergy 10, 36–39 (1938). Ref. Zbl. Bakter. 134, 76.Google Scholar
  105. 105.
    van der Schueren, G.: Influence d’extraits tumoraux sur le virus et l’infection staphylococcique. C. r. Soc. Biol. Paris 120, 261–263 (1935).Google Scholar
  106. 106.
    Schultz, M. P. and E. J. Rose: The evolution of disseminated bacterial infection in guinea-pigs. Influence of treatment with insulin and phloridzin. Publ. Health Rep. 54, 657 (1939).Google Scholar
  107. 107.
    Shwartzman, G.: The phenomenon of local skin reactivity to bacterial filtrates: Elicitation of local reactivity by way of the vascular system. J. of exper. Med. 62, 621–644 (1935).Google Scholar
  108. 108.
    Seastone, C.V.: Hemolytic streptococcus: Lymphadenitis in guinea pigs. J. of exper. Med. 70, 347–359 (1939).Google Scholar
  109. 109.
    Seastone, C.V.: The virulence of group C. hemolytic Streptococci of animal origin. J. of exper. Med. 70, 361–378 (1939).Google Scholar
  110. 110.
    Spinelli, A.: Osservazioni intarno alla influenza di estratti di organo sulla permeabilité dei tessuti. Azione dagli estratti tiroidei. Riv. Pat. sper. 9, 203–211 (1932).Google Scholar
  111. 111.
    Sprunt, D.H., Ch. W. Hooker and J. S. Raper: Relation of spermatogenesis to the factor in the testis which increases tissue permeability. Proc. Soc. exper. Biol. a. Med. 41, 398–402 (1939).Google Scholar
  112. 112.
    Stewart, Fr. W. and F. Duran-Reynals: A study of the generalization of vaccine virus from enhanced skin lesions. J. of exper. Med. 50, 341–353 (1929).Google Scholar
  113. 113.
    Tanzer, R. C: The effect of testicle extract on the growth of transplantable Mouse tumors. J. of exper. Med. 55, 455–463 (1932).Google Scholar
  114. 114.
    Thomas, R. M. and F. Duran-Reynals: The Degree of dispersion of the bacillus as a factor in infection and resistance in experimental tuberculosis. Proc. Soc. exper. Biol. a. Med. 31, 1201 (1934). – J. of exper. Med. 52, 39–64 (1935).Google Scholar
  115. 115.
    Thompson, R.: Experiments with the virus of poliomyelitis. J. of exper. Med. 51, 777–785 (1930).Google Scholar
  116. 116.
    Tullio, Gruffré: Experimentaluntersuchung über die Veränderung der Diffusion des Hodenextraktes bei Tieren mit Brandwunden. Boll. Ist. sieroter. milan. 18, 517 bis 526 (1939).Google Scholar
  117. 117.
    Walker, T. T. and D. C. Hoffman: The effect of testicular extract on experimental tuberculosis in rabbits. I. Skin lesions. Amer. J. Path. 9, 651–657 (1933).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1941

Authors and Affiliations

  • H. Schmidt Marburg
    • 1
  1. 1.Instituts für experimentelle Therapie „Emil v. Behring“Marburg a. d. LahnDeutschland

Personalised recommendations