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Comparative Effects of 1α-hydroxycholecalciferol in Children and Adults with Renal Glomerular Osteodystrophy

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Calcified Tissues 1975

Abstract

Recent short-term studies have shown that microgram doses of both 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), the hormonally active metabolite of vitamin D, and lα-hydroxycholecalciferol (lα-OH-D3), a synthetic analogue can increase intestinal absorption of calcium in patients with chronic renal failure in whom large (mg) doses of vitamin D are ineffective (1, 4, 5, 6). In patients with renal osteodystrophy, these compounds may reduce plasma parathyroid hormone concentration and osteoclastic bone resorption (2) and increase the calcium content of the bones of the hands (3). There is, however, little published work on the long-term effects of 1,25-(OH)2-D3 or lα-OH-D3 in patients with renal osteodystrophy. The present paper describes the effects of lα-OH-D3 in four children and three adults studied for up to 14 months.

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References

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Authors and Affiliations

  1. Renal Unit, Churchill Hospital, Oxford, England

    R. G. Henderson, J. A. Kanis, J. G. G. Ledingham, D. O. Oliver, R. G. G. Russel, R. Smith & R. J. Walton

  2. Metabolic Unit, Nuffield Departments of Orthopaedic Surgery, Oxford, England

    R. G. Henderson, J. A. Kanis, J. G. G. Ledingham, D. O. Oliver, R. G. G. Russel, R. Smith & R. J. Walton

  3. Clinical Medicine, University of Oxford, Oxford, England

    R. G. Henderson, J. A. Kanis, J. G. G. Ledingham, D. O. Oliver, R. G. G. Russel, R. Smith & R. J. Walton

Authors
  1. R. G. Henderson
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  2. J. A. Kanis
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  3. J. G. G. Ledingham
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  4. D. O. Oliver
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  5. R. G. G. Russel
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  6. R. Smith
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  7. R. J. Walton
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Editor information

S. Pors Nielsen E. Hjørting-Hansen

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© 1976 Springer-Verlag Berlin Heidelberg

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Henderson, R.G. et al. (1976). Comparative Effects of 1α-hydroxycholecalciferol in Children and Adults with Renal Glomerular Osteodystrophy. In: Nielsen, S.P., Hjørting-Hansen, E. (eds) Calcified Tissues 1975. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29272-3_32

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  • DOI: https://doi.org/10.1007/978-3-662-29272-3_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-27776-8

  • Online ISBN: 978-3-662-29272-3

  • eBook Packages: Springer Book Archive

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