Abstract
Since Harrison carried out his fundamental experiments on the antiphosphaturic renal effect of vitamin D (5) a number of clinical and experimental observations have been made trying to elucidate the effect of vitamin D and/or the interaction with PTH on renal transport of phosphate. Results obtained by various authors have often been controversial (1, 6, 8, 9, 10). The difficulties encountered in interpreting the changes in urinary excretion of phosphate have been related to the following experimental conditions: 1) hypercalcaemic action of vitamin D, 2) experimental animals are volume expanded, 3) different effects of physiological and pharmacological doses of PTH and vitamin D or its metabolites, 4) experimental animals without vitamin D deficiency, 5) “acute” studies.
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© 1976 Springer-Verlag Berlin Heidelberg
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Jelonek, A. (1976). Interaction of Parathyroid Hormone and 25-hydroxycholecalciferol on Renal Handling of Phosphate. In: Nielsen, S.P., Hjørting-Hansen, E. (eds) Calcified Tissues 1975. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29272-3_24
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DOI: https://doi.org/10.1007/978-3-662-29272-3_24
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