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Immune Phenomena in Pernicious Anaemia

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Current Problems in Immunology

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 1))

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Abstract

The clinical observation of patients with pernicious anaemia who ceased to respond to hog-intrinsic factor preparations after prolonged oral treatment (Schwartz, Taylor) suggested almost 10 years ago that immune processes may play a role in the pathogenesis of this disease. In early trials with pernicious anaemia patients Schwartz, Denmark, succeeded in 1958, simultaneously with Taylor in England, in inhibiting the therapeutical effect of intrinsic factor by previous contact with the serum of certain pernicious anaemia patients. With refined immunological in vitro techniques it was possible to confirm and more closely to investigate the antibody nature of this serum factor blocking intrinsic factor activity (Ardeman, Chanarin, Abels et al., Gottlieb et al., Herbert et al., Jeffries, Sleisinger). Besides the immunological principle active against intrinsic factor, English authors (Taylor et al., Irvine) found another antibody system reacting specifically with antigens of the gastric mucosa in pernicious anaemia and also in certain forms of chronic atrophic gastritis which are now considered as subclinical stages of pernicious anaemia (Dagg, Markson, Moore). This duality of antibody systems in pernicious anaemia shows distinct parallels to the immunological background of Hashimoto’s thyroiditis. In both diseases chronic inflammatory processes in the “target organ” of the immunological process, i.e. thyroid or gastric mucosa, lead to destruction of the organ parenchyma and thus cause cessation of secretory function. In view of the obvious relationship between the immunological phenomena, expressed also in a mutual overlapping of serological findings in pernicious anaemia and autoimmune thyroiditis, pernicious anaemia was soon regarded as belonging to the group of autoimmunopathies, before it was possible to provide exact serological proof of the autospecificity of the antibodies.

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Authors and Affiliations

  1. Medizinische Universitätsklinik, 74 Tübingen, Olfried-Müller-Straße, Germany

    Priv.-Doz. Dr. W. Hartl

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  1. Priv.-Doz. Dr. W. Hartl
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Editors and Affiliations

  1. Max-Planck-Instituts für Immunbiologie, Stübeweg 51, 7800, Freiburg-Zähringen, Deutschland

    Otto Westphal (Direktor) (Direktor)

  2. Medizinischen Klinik der Universität, Olfried-Müller-Straße, 7400, Tübingen, Deutschland

    Hans-Erhard Bock (Direktor) (Direktor)

  3. Instituts für experimentelle Pathologie, Farbenfabriken Bayer AG, 5600, Wuppertal-Elberfeld, Deutschland

    Ekkehard Grundmann (Vorstand) (Vorstand)

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Hartl, W. (1969). Immune Phenomena in Pernicious Anaemia. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29237-2_21

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  • DOI: https://doi.org/10.1007/978-3-662-29237-2_21

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