Abstract
Fifteen years ago advances in immunogenetics and in transplantation biology provided the means by which the antigenicity of tumors was first demonstrated. Now that several well-defined systems of tumor antigens are available for study, research has entered the phase of investigation into the origin and nature of these antigens, and the techniques of classical immunology and of immunochemistry assume increasing importance. Serological methods, for instance, have played an important part in the analysis of antigens of virus-induced tumors. By contrast, they have been of little value in the study of tumors induced by chemical carcinogens, where it has been shown clearly that tumors induced in mice and rats at the site of subcutaneous injection of polycyclic hydrocarbons carry antigens capable of eliciting transplantation resistance in isogenic and even primary hosts (Old and Boyse, 1964; Prehn, 1965; Klein, Prehn, 1967). These transplantation antigens are unique for each individual tumor; immunization with any one tumor induces resistance to that tumor and generally no other. Transplantation immunity can be transferred to non-immune recipients by means of cells from the spleen, lymph nodes or peritoneal cavity of immunized donors; serum from such donors does not confer resistance. Although antibody to surface components of the tumor cell has been demonstrated (Moeller, Old et al., 1963; Lejneva et al., 1965; Stueck, 1967; Harder and McKhann, 1968), it is not clear whether the antigens detected by these techniques are related to the tumor-specific transplantation antigens.
Supported by Grants CA 08748, AIO 7118 and CA 08145 of the National Cancer Institute, Grant DRG 956A of the Damon Runyon Memorial Fund, and a grant from the Fleischmann Foundation.
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Oettgen, H.F., Old, L.J., McLean, E.P., Bloom, B.R., Bennett, B. (1969). Delayed Hypersensitivity and Tumor Specific Immunity. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29237-2_17
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