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Hepatocellular Carcinoma, Liver, Rat

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Digestive System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY,volume 3))

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Abstract

Hepatocellular carcinomas are usually visible grossly and range in size from several millimeters to several centimeters (Farber 1976; Greenblatt and Lijinsky 1972; Goodman et al. 1994; Fig. 34). They are roughly spherical, although multilo-bulation may distort the shape (Fig. 35), and appear as single or multiple, light-tan to dark-red lesions in the liver. Rats chronically exposed to potent hepatocarcinogens frequently have multiple hepatocellular carcinomas alone or in combination with hepatocellular adenomas (Fig. 34). The liver of such an animal may be almost totally replaced by numerous, variably sized neoplastic and preneoplastic lesions.

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Authors
  1. James A. Popp
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  2. Russell C. Cattley
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Editor information

Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street. N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) (Professor of Comparative Pathology, Emeritus)

  2. Sanofi Winthrop, Toxicology U.S., Nine Great Valley Parkway, Malvern, PA, 19355, USA

    James A. Popp D.V.M., Ph.D. (International Director of Toxicology, Vice President) (International Director of Toxicology, Vice President)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1997 Springer-Verlag Berlin Heidelberg

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Popp, J.A., Cattley, R.C. (1997). Hepatocellular Carcinoma, Liver, Rat. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_4

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  • DOI: https://doi.org/10.1007/978-3-662-25996-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-0-944398-75-3

  • Online ISBN: 978-3-662-25996-2

  • eBook Packages: Springer Book Archive

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