Abstract
The macroscopic appearance of abdominal mesotheliomas is variable depending upon the extent of organ involvement. Early tumors may be identified as no more than a localized, occasionally nodular thickening of the peritoneal, diaphragmatic, or organ serosal surface, whereas more extensive tumors are typically diffuse, involving almost all abdominal organs with extensive infiltration and adhesions and relatively large masses of neoplastic tissue. Unattached tumor or fibrous nodules are often reported in the abdominal cavity. Spread beyond the abdominal cavity is rarely observed. Fibrous nodules and early fiber-induced mesotheliomas tend to be discolored with accumulations of injected fibers; otherwise mesotheliomas are white to cream or yellow in color, with a firm consistency. Hemorrhagic ascites frequently accompany mesothelioma development.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Adachi S, Yoshida S, Kawamura K, Takahashi M, Uchida H, Odagiri Y, Takemoto K (1994) Inductions of oxidative DNA damage and mesothelioma by crocidolite, with special reference to the presence of iron inside and outside of asbestos fiber. Carcinogenesis 15:753–758
Brown DG, Johnson NF, Wagner MM (1985) Multipotential behaviour of cloned rat mesothelium cells with epithelial phenotype. Br J Cancer 51:245–252
Coffin DL, Cook PM, Creason JP (1992) Relative mesothelioma induction in rats by mineral fibers: comparison with residual pulmonary mineral fiber number and epidemiology. Inhal Toxicol 4:273–300
Collier CG, Morris KM, Launder KA, Humphreys JA, Morgan A, Eastes W, Townsend S (1995) The behaviour of glass fibers in the rat following intraperitoneal injection. J Reg Toxicol Pharmacol 20:589
Davis JM (1979) The histopathology and ultrastructure of pleural mesotheliomas produced in the rat by injections of crocidolite asbestos. Br J Exp Pathol 60:642–652
Davis JM, Jones AD (1988) Comparisons of the pathogenicity of long and short fibres of chrysotile asbestos in rats. Br J Exp Pathol 69:717–737
Davis JM, Addison J, Bolton RE, Donaldson K, Jones AD, Smith T (1986) The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol 67:415–430
Edwards RE, Wagner MM, Moncrieff CB (1984) Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Br J Ind Med 41:506–513
Fraire AE, Greenburg SD, Spjut HJ, Roggli VL, Dodson RF, Cartwright J, Williams G, Baker S (1994) Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations. Am J Respir Crit Care Med 150:521–527
Friemann J, Müller KM, Pott F (1990) Mesothelial proliferation due to asbestos and man-made fibres. Experimental studies on rat omentum. Pathol Res Pract 186:117–123
Hahn FF, Lundgren DL (1992) Pulmonary neoplasms in rats that inhaled cerium-144 dioxide. Toxicol Pathol 20:169–178
Hall W (1990) Peritoneum, retroperitoneum, mesentry, and abdominal cavity. In: Boorman GA, Eustis SL, Elwell MR (eds) Pathology of the Fischer rat: reference and atlas. Academic, San Diego, pp 63–69
Hesterberg TW, Mast R, McConnell EE, Chevalier J, Bernstein DM, Bun WB, Anderson R (1991) Chronic inhalation toxicity of refractory ceramic fibers in Syrian hamsters. In: Brown RC, Hoskins JA, Johnson NF (eds) Mechanisms in fibre carcinogenesis. Plenum, New York, pp 531–538
Hill RJ, Edwards RE, Carthew P (1990) Early changes in the pleural mesothelium following the intrapleural inoculation of the mineral fiber erionite and the subsequent development of mesotheliomas. J Exp Pathol 71:105–118
Lee MM, Green FH, Demetrick DJ, Jiang XX, Schürch S (1993) A study of surface property changes in rat mesothelial cells induced by asbestos using aqueous two-phase polymer solutions. Biochem Biophys Acta 1181:223–232
Pott F (1978) Some aspects on the dosimetry of the carcinogenic potency of asbestos and other fibrous dusts. Staub Reinhalt Luft 38:486–490
Pott F, Friedrichs KH (1972) Tumoren der Ratte nach ip-Injektion faserformiger Staube. Naturwissenschaften 59:318
Pott F, Roller M, Ziem U, Reiffer FJ, Bellmann B, Rosenbruch M, Hath F (1989) Carcinogenicity studies on natural and man-made fibers with the intraperitoneal test in rats. In: Bignon J, Peto J, Saracci R (eds) Non-occupational exposure to mineral fibres. IARC, Lyon, pp 175–179 (IARC scientific publications no 90)
Pott F, Bolme H, Bruch J, Friedberg KD, Rödesisperger K, Woitowitz H-J (1990) Einstufungsvorschlag für Anorganische und Oranische Fasern. Arbeitsmed Soziamed Praventivmed 25:463–466
Rittinghausen S, Ernst H, Muhle H, Fuhst R, Mohr U (1991) Histopathological analysis of tumor types after intraperitoneal injection of mineral fibres in rats. In: Brown RC, Hoskins JA, Johnson NF (eds) Mechanisms in fibre carcinogenesis. Plenum, New York, pp 81–89
Sahu SC (1991) Role of oxygen free radicals in the molecular mechanisms of carcinogenesis: a review. Environ Carcino Ecotox Revs C9:83–112
Sanders CL (1992) Pleural mesothelioma in the rat following exposure to 239PuO2. Health Phys 63:695–697
Smith DM, Ortiz LW, Archuleta RF, Johnson NF (1987) Long-term health effects in hamsters and rats exposed chronically to man-made vitreous fibers. Ann Occup Hyg 31:731–754
Stanton MF, Wrench C (1972) Mechanisms of mesothelioma induction with asbestos and fibrous glass. J Natl Cancer Inst 48:797–821
Stanton MF, Laynard M (1978) The carcinogenicity of fibrous materials. In: Gravatt CC, Lafleur PD, Heinrich FJ (eds) Workshop on asbestos: definitions and measurement methods. National Bureau of Standards, Washington DC (NBS special publication no 506)
Stanton MF, Laynard M, Tegeris A, Miller E, May M, Morgan E, Kent E (1977) Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst 58:587–603
Wagner JC (1990) Significance of the fiber size of erionite. Abstract in National Institute for Occupational Safety and Health. Proceedings of the Vllth international pneumoconioses conference, 23–26 Aug 1988, Pittsburgh, Pennsylvania, USA. Part I. Pittsburgh (PA): US Department of Health and Human Services 158. DHHS (NIOSH) publication no 90–108, part I
Wagner JC, Munday DE, Harrison JS (1962) Histochemical demonstration of hyaluronic acid in pleural mesotheliomas. J Pathol Bacteriol 84:73
Wagner JC, Johnson NF, Brown DG, Wagner MM (1982) Histology and ultrastructure of serially transplanted rat mesotheliomas. Br J Cancer 46:294–299
Wagner JC, Skidmore JW, Hill RJ, Griffiths DM (1985) Erionite exposure and mesotheliomas in rats. Br J Cancer 51:727–730
Yang GH, Tan YS, Liu XZ, Luo SQ (1988) Ultrastructure and immunohistochemical study of mesothelioma induced by asbestos in rat. Hua Hsi I Ko Hsueh Hsueh Pao 19:337–341
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Brooks, P.N., Collier, C.G. (1997). Mesothelioma, Peritoneum, Induced by Mineral Fibers, Rat. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_14
Download citation
DOI: https://doi.org/10.1007/978-3-662-25996-2_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-0-944398-75-3
Online ISBN: 978-3-662-25996-2
eBook Packages: Springer Book Archive