Concepts and Observations on the Regulation of Granulocyte Production

  • E. P. Cronkite
  • H. Burlington
  • A. D. Chanana
  • D. D. Joel
  • U. Reincke
  • J. Stevens


In dogs the neutrophilic granulocyte count in the blood responds quickly to infection. Marsh et al. (22) showed that neutrophils were two to three times normal within 6 hr after induction of bacterial pneumonia in dogs. Furthermore, the ratio of nonsegmented to segmented neutrophils increased progressively, showing a rapid release from the bone marrow of less mature cells. Under normal steady-state conditions there are modest fluctuations in the blood granulocyte count, presumably the result of an interplay among factors regulating the sojourn time in the blood, rate of release of granulocytes from the bone marrow, their rate of production in the bone marrow, and the factors that inhibit marrow granulocyte production. In fact, Morley et al. (26) believe there is a periodic cycling of normal granulocyte count, in man, as a result of this interplay.


Bone Marrow Sojourn Time Tritiated Thymidine Storage Pool Granulocyte Count 
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • E. P. Cronkite
  • H. Burlington
  • A. D. Chanana
  • D. D. Joel
  • U. Reincke
  • J. Stevens

There are no affiliations available

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