Experimental Chemotherapy: A Rat Model for Human Acute Myeloid Leukemia

  • Loes P. Colly
  • Ton Hagenbeek


Significant advances have been made in the management of human actue myelocytic leukemia (AML) over the last decade (5,6). However, the overall remission induction rate and survival time are still less than obtained in other types of leukemia, e.g., acute lymphocytic leukemia (ALL) (3,8). An animal leukemia model analogous to human AML would be helpful in the design of experimental therapy regimens. Two prerequisites for the relevance of such a model are (1) a slow overall growth rate of the leukemia, and (2) a suppression of normal hemopoiesis that runs the same course as that in the human disease (10,11).


Cytosine Arabinoside Brown Norway Peripheral White Blood Cell Normal Hemopoiesis Human Acute Myeloid Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. (1).
    van Bekkum, D. W., and de Vries, M. J. in Radiation Chimeras. New York: Academic Press, 1967.Google Scholar
  2. (2).
    van Bekkum, D. W., van Oosterom, P., and Dicke, K. A. In vitro colony formation of transplantable rat leukemias in comparison with human acute myeloid leukemia. Cancer Res., 36:941, 1976.Google Scholar
  3. (3).
    Berry, D. H., Pullen, J., George, St., Vietti, T. J., Sullivan, M. P., and Frenbach, D. Comparison of prednisone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia. Cancer, 36: 98, 1975.PubMedCrossRefGoogle Scholar
  4. (4).
    McCredie, K. B., Bodey, G. P., Gutterman, J. U., Rodriquez, V., and Freireich, E. J. Sequential Adriamycin-Ara-C (A-OAP) for remission induction of adult acute leukemia (AAL). Proc. Am. Assoc. Cancer Res., 15: 62, 1974.Google Scholar
  5. (5).
    European Organization for research on Treatment of Cancer (EORTC). (Leukemia and hematosarcoma cooperative group.) A second comparative trial of remission induction (by Cytosine Arabinoside given every 12 hours, or CAR and thioguanine, or CAR and daunorubine) and maintenance therapy (by CAR or methylgag) in Acute Myeloid leukemia. Eur. J. Cancer, 10:413,1974.Google Scholar
  6. (6).
    Gutterman, J. U., Rodriquez, V., Marligit, J. Burgess M. A., Geham, E., Hersch, M., McCredie, K. B., Reed, R., Smith, T., Bodey, Sr. S. P., and Freireich, E. J. Chemoimmünotherapy of adult acute leukemia. Prolongation of remission in myeloblastic leukemia with BCG. Lancet, 1:1405, 1974.Google Scholar
  7. (7).
    Hoelzer, D. Growth characteristics of a transferable acute leukemia in rats. J. Natl. Cancer Inst., 50: 1321, 1973.PubMedGoogle Scholar
  8. (8).
    Mauer, A. M., and Simone, J. V. The current status of the treatment of childhood acute lymphoblastic leukemia. Cancer Treatment. Rev., 3:17, 1976.Google Scholar
  9. (9).
    Moloney, W. C., Dorr, A. D., Dowd, G., and Boschetti, A. E. Myelogenous leukemia in the rat. Blood, 19: 45, 1962.PubMedGoogle Scholar
  10. (10).
    Moore, M. A. S., Spitzer, G., Williams, N., Metcalf, D., and Buckley, J. Agar culture Studies in 127 cases of untreated acute leukemia: The prognostic value of reclassification of leukemia according to in vitro growth characteristics. Blood, 44:2, 1974.Google Scholar
  11. (11).
    Moore, M. A. S. In vitro studies in the myeloid leukemias. In Cleton, F. C. Crowther, D. C., and Malpas, J. S., eds., Advances in Acute leukemia, Chapter 7. Amsterdam: North-HollandAmerican Elsevier, 1974.Google Scholar
  12. (12).
    Skipper, H. E., Schnabel, F. M., Trader, M. W., Laster, W. R., Simpson-Herren, L., and Lloyd, H. H. Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-End of 1971. Cancer Chemother. Rep., 56: 273, 1972.PubMedGoogle Scholar
  13. (13).
    Till, J. E., and McCulloch, E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res., 14: 213, 1961.PubMedCrossRefGoogle Scholar
  14. (14).
    Wodinsky, J., Suiniorski, J., and Kensler, C. J. Spleen colony studies of leukemia L1210. 1. Growth kinetics of lymphocytic L1210 cells in vivo as determined by spleen colony assay. Cancer Chemother. Rep., 51: 415, 1976.Google Scholar
  15. (15).
    Zbinden, G., and Bränle, E. Toxicologie screening of daunorubicin (NSC-82151), adriamycin (NSC-1213127) and their derivatives in rats. Cancer Chemother. Rep., 59: 707, 1975.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Loes P. Colly
  • Ton Hagenbeek

There are no affiliations available

Personalised recommendations