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Experimental Chemotherapy: A Rat Model for Human Acute Myeloid Leukemia

  • Loes P. Colly
  • Ton Hagenbeek

Abstract

Significant advances have been made in the management of human actue myelocytic leukemia (AML) over the last decade (5,6). However, the overall remission induction rate and survival time are still less than obtained in other types of leukemia, e.g., acute lymphocytic leukemia (ALL) (3,8). An animal leukemia model analogous to human AML would be helpful in the design of experimental therapy regimens. Two prerequisites for the relevance of such a model are (1) a slow overall growth rate of the leukemia, and (2) a suppression of normal hemopoiesis that runs the same course as that in the human disease (10,11).

Keywords

Cytosine Arabinoside Brown Norway Peripheral White Blood Cell Normal Hemopoiesis Human Acute Myeloid Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Loes P. Colly
  • Ton Hagenbeek

There are no affiliations available

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