Abstract
Within the past few years, attempts to restructure damaged or deficient circuitry within the central nervous system (CNS) have involved the use of fetal CNS tissue transplants as specific replacements (Lund and Hauschka 1976, Perlow et al. 1979, Gash et al. 1980). Necessarily, the placement of grafts in these systems involves damage to the host brain. Experimental methods entail either direct insertion into the parenchyma or the establishment of a resection cavity for subsequent graft placement (Das and Altman 1972, Stenevi et al. 1976, Björklund and Stenevi 1979). Either means, although successful in terms of connectivity, may produce not only an extensive astroglial reaction but the ensuing brain wound violates the blood—brain barrier (BBB) and thus serves to liberate systemically derived macrophages (see Imamoto and LeBlond 1977).
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Rosenstein, J.M., Brightman, M.W. (1986). Cellular Interactions between Transplanted Autonomic Ganglia and the Developing Brain. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25264-2_11
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DOI: https://doi.org/10.1007/978-3-662-25264-2_11
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