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Glutamate Receptors, Nitric Oxide, and Cyclic GMP

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Excitatory Amino Acids and Second Messenger Systems

Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 3))

Abstract

In the 1970s, well before acidic amino acids were recognised as the major excitatory neurotransmitters in the central nervous system (CNS), it was found that application of glutamate by microinjection in vivo or to brain slices in vitro, was able to provoke large increases in the levels of cyclic guanosine monophosphate (cGMP) [1, 2]. A few years later, it was demonstrated that activation of excitatory pathways in vivo would also produce this response [3, 4] suggesting the involvement of synaptic mechanisms.

The laboratory research in this study was supported by the MRC (UK).

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Authors
  1. John Garthwaite
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  2. Eric Southam
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  3. Stephen J. East
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Editor information

Editors and Affiliations

  1. Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel

    Vivian I. Teichberg

  2. Department of Neuropsychopharmacology, Schering AG, Müllerstraße 170 - 178, P.O. Box 650311, D-1000, Berlin 65, Germany

    Lechoslaw Turski

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© 1991 Springer-Verlag Berlin Heidelberg

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Garthwaite, J., Southam, E., East, S.J. (1991). Glutamate Receptors, Nitric Oxide, and Cyclic GMP. In: Teichberg, V.I., Turski, L. (eds) Excitatory Amino Acids and Second Messenger Systems. Schering Foundation Workshop, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22666-7_7

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  • DOI: https://doi.org/10.1007/978-3-662-22666-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22668-1

  • Online ISBN: 978-3-662-22666-7

  • eBook Packages: Springer Book Archive

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