Skip to main content
SpringerLink
Log in

Histopathology

  • Chapter
Wilms Tumor: Clinical and Molecular Characterization

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

  • 52 Accesses

Abstract

Since the first well-documented morphological descriptions of nephroblastoma,1,2 which preceded Max Wilms’ landmark monograph “Die Mischgeschwülste der Niere”3 by two decades, information on the morphology of Wilms tumors has accumulated rapidly. Histopathologic studies conducted under the auspices of both the North American National Wilms Tumor Study (NWTS) and the European International Society of Paediatric Oncology (SIOP) have resulted in an extensive body of literature concerning the histomorphology of this childhood neoplasm. Traditionally viewed as a triphasic embryonal renal tumor, it is now clear that some Wilms tumors may be biphasic or even monomorphic, causing some differential diagnostic challenges. This chapter intends to provide a basic understanding of some of the histopathologic features of childhood renal tumors, including Wilms tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eberth CJ: Myoma sarcomatodes renum. Virchows Arch 1872; 55: 518–520.

    Article  Google Scholar 

  2. Cohnheim J: Congenitales, quergestreiftes Muskelsarcom der Nieren. Virchows Arch Pathol Anat Physiol 1875; 65: 64–69.

    Article  Google Scholar 

  3. Wilms M: Die Mischgeschwülste der Niere. Leipzig: Verlag von Arthur Georgi, 1899: 1–90.

    Google Scholar 

  4. Green DM, D’Angio GJ, Beckwith JB, Breslow N, Finklestein J, Kelalis P, Thomas P: Wilms’ tumor (Nephroblastoma, renal embryoma). In Pizzo PA and Poplack DG (eds): Principles and Practice of Pediatric Oncology. Philadelphia: J.B. Lippincott Company, 1993: 713–737.

    Google Scholar 

  5. Gonzalez-Crussi F: The pathology of Wilms’ tumor. In: GonzalezCrussi F (eds): Wilms’ Tumor (Nephroblastoma) and Related Renal Neoplasms of Childhood. Boca Raton, Florida: CRC Press, 1984: 177–206.

    Google Scholar 

  6. Beckwith JB: Wilms’ tumor and other renal tumors of childhood. In: Finegold M (eds): Pathology of Neoplasia in Children and Adolescents. Philadelphia: WB Saunders Company, 1986: 313–332.

    Google Scholar 

  7. Mierau GW, Weeks DA, Beckwith JB: Ultrastructure and histogenesis of the renal tumors of childhood: An overview. Ultrastruct Pathol 1987; 11: 313–333.

    Article  PubMed  CAS  Google Scholar 

  8. Altmannsberger M, Osborn M, Schäfer H, Schauer A, Weber K: Distinction of nephroblastomas from other childhood tumors using antibodies to intermediate filaments. Virchows Archiv B 1984; 45: 113–124.

    Article  CAS  Google Scholar 

  9. Lawler W, Marsden HB, Palmer ML: Wilms’ tumor-histologic variations and prognosis. Cancer 1975; 40: 1122–1126.

    Article  Google Scholar 

  10. Chatten J: Epithelial differentiation in Wilms’ tumor: A clinico-pathologic appraisal. Perspect Pediatr Pathol 1976; 3: 225–254.

    PubMed  CAS  Google Scholar 

  11. Chambers CH, Camitta BM, Tang TT, McCreadie SR: Nephroblastoma (Wilms’ tumor): Tubule density and prognosis. Med Pediatr Oncol 1978; 5: 127–135.

    Article  PubMed  CAS  Google Scholar 

  12. Beckwith JB: Grading pediatric tumors. Care of the child with cancer. New York: American Cancer Society, 1979: 39–44.

    Google Scholar 

  13. Bonadio JF, Storer B, Norkool P, Farewell VT, Beckwith JB, D’Angio GJ: Anaplastic Wilms’ tumor: clinical and pathological studies. J Clin Oncol 1985; 3: 513–520.

    PubMed  CAS  Google Scholar 

  14. Beckwith JB, Palmer NF: Histopathology and prognosis of Wilms’ tumor. Results from the first National Wilms’ Tumor Study. Cancer 1978; 41: 1937–1948.

    Article  PubMed  CAS  Google Scholar 

  15. Delemarre JFM, Sandstedt B, Gérard-Marchant R, Tournade MF. SIOP nephroblastoma trials and studies, morphological aspects. In the proceedings of the 136 meeting of the International Society of Paediatric Oncology, September 15–19, 1981. Mareseille: Exerpta Medica, 1982.

    Google Scholar 

  16. Zuppan CW, Beckwith JB, Luckey DW: Anaplasia in unilateral Wilms’ tumor: A report from the National Wilms’ Tumor Study Pathology Center. Human Pathol 1988; 19: 1199–209.

    Article  CAS  Google Scholar 

  17. Faria P, Beckwith JB: A new definition of focal anaplasia (FA) in Wilms tumor (WT) identifies cases with good outcome. A report from the National Wilms tumor Study. Mod Pathol 1993; 6: 3 p.

    Google Scholar 

  18. Bennington JL, Beckwith J: Tumors of the kidney, renal pelvis, and ureter (Fasc.12). In Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology, 1975.

    Google Scholar 

  19. Bove KE, McAdams AJ: The nephroblastomatosis complex and its relationship to Wilms’ tumor: A clinicopathologic treatise. Perspect Pediatr Pathol 1976; 3: 185–223.

    PubMed  CAS  Google Scholar 

  20. Beckwith JB, Kiviat NB, Bonadio JF: Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’ tumor. Pediatr Pathol 1990; 10: 1–36.

    Article  PubMed  CAS  Google Scholar 

  21. Fine H: The developments of the lobes of the metanephros and fetal kidney. Acta Anat (Basel) 1982; 113: 93–107.

    Article  CAS  Google Scholar 

  22. Inke G: The protolobar structure of the human kidney: Its biologic and clinical significance. New York: Alan R Liss, 1988.

    Google Scholar 

  23. Beckwith JB: Precursor lesions of Wilms tumor: clinical and biological implications. Med Pediatr Oncol 1993; 21: 158–168.

    Article  PubMed  CAS  Google Scholar 

  24. Park S, Bernard A, Bove KE, Sens DA, Hazen-Martin DJ, Garvin HA, Haber DA: Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms’ tumour. Nature Genetics 1993; 5: 363–367.

    Article  PubMed  CAS  Google Scholar 

  25. Bolande RP, Brough AJ, Izant RJ: Congenital mesoblastic nephroma of infants. A report of eight cases and the relationship to Wilms’ tumor. Pediatrics 1976; 40: 272–278.

    Google Scholar 

  26. Howell CG, Othersen HB, Kiviat NE, Norkool P, Beckwith JB, D’Angio GJ: Therapy and outcome in 51 children with mesoblastic nephroma: A report of the National Wilms’ Tumor Study. J Pediatr Surg 1982; 17: 826–831.

    Article  PubMed  CAS  Google Scholar 

  27. Sandstedt BE, Delemarre JFM, Krul EJ, Tournade MF: Mesoblastic nephromas: A study of 29 tumours from the SIOP nephroblastoma file. Histopathology 1985; 9: 741–750.

    Article  PubMed  CAS  Google Scholar 

  28. Beckwith JB, Kiviat NB: Multilocular renal cysts and cystic renal tumors. Am J Roentgenol 1981; 136: 435–436.

    Article  CAS  Google Scholar 

  29. Snyder HM, Lack E, Chetty-Baktavizion S, Brauer SB, Colodna AM, Retik AB: Congenital mesoblastic nephroma: Relationship to other renal tumors in infancy. J Urol 1981; 126: 513–516.

    PubMed  Google Scholar 

  30. Coppes MJ, Bonetta L, Huang A, Hoban P, Chilton-MacNeill S, Campbell CE, Weksberg R, Yeger H, Reeve AE, Williams BRG: Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for non-disjunction or mitotic recombination. Genes Chrom Cancer 1992; 5: 326–334.

    Article  PubMed  CAS  Google Scholar 

  31. Tomlinson GE, Argyle JC, Velasco S, Nisen PD: Molecualr characterization of congenital mesoblastic nephroma and its distinction from Wilms tumor. Cancer 1992; 70: 2358–2361.

    Article  PubMed  CAS  Google Scholar 

  32. Kidd JM: Exclusion of certain renal neoplasms from the category of Wilms’ tumor. Am J Pathol 1970; 59: 16a.

    Google Scholar 

  33. Marsden HB, Lawler W, Kumar PM: Bone metastazing renal tumor of childhood. Morphological and clinical features, and differences from Wilms’ tumor. Cancer 1978; 42: 1922–1928.

    Article  PubMed  CAS  Google Scholar 

  34. Sandstedt BE, Delemarre JFM, Harms D, Tournade MF: Sarcomatous Wilms’ tumour with clear cells and hyalinization. A study of 38 tumours in children from the SIOP nephroblastoma file. Histopathology 1987; 9: 273–285.

    Article  Google Scholar 

  35. Haas JE, Bonadio JF, Beckwith JB: Clear cell sarcoma of the kidney with emphasis on ultrastructural studies. Cancer 1984; 54: 2978–2987.

    Article  PubMed  CAS  Google Scholar 

  36. Stassinopolou A, Tournade MF, Ducourtieux M, Terrier-Lacombe MJ, Habrand JL, Gruner M, Valteau-Couanet D, Lemerle J: The malignant rhabdoid tumor (MRT) of the kidney: A rare but unsolved problem. Med and Pediatr Oncol 1991; 19: 389.

    Google Scholar 

  37. Palmer NF, Sutow W: Clinical aspects of the rhabdoid tumor of the kidney: A report from the National Wilms’ Tumor Study Group. Med Pediatr Oncol 1983; 11: 242–245.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada

    Max J. Coppes M.D., Ph.D.

  2. Department of Cancer Biology Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Christine Campbell Ph.D. & Bryan R. G. Williams Ph.D.

Authors
  1. Max J. Coppes M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine Campbell Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bryan R. G. Williams Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Coppes, M.J., Campbell, C., Williams, B.R.G. (1995). Histopathology. In: Wilms Tumor: Clinical and Molecular Characterization. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22621-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-22621-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22623-0

  • Online ISBN: 978-3-662-22621-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation