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The Role of Oxidative Stress in Neuronal Death pp 99–139Cite as

Oxidative Stress in Alzheimer’s Disease

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Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

Abstract

It has been nearly 90 years since Alois Alzheimer first described the dementing illness asso-ciated with his name.l AD is the most common cause of progressive cognitive decline in the aged population and the most prevalent neurodegenerative disease affecting more than 15 million people wordwile. AD shares the triad hallmark features of β-amyloid plaques (senile plaques; SP), neurofibrillary tangles (NFT) with extensive neuronal loss, particularly in the hippocampus and cerebral cortex, and dementia, which appear to arise sporadically and are typically late in onset (after the age of 65). Familial ADs (FAD) exist and frequently display a much earlier onset of the disease (age 40–50 years).

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    Irène Ceballos-Picot

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Ceballos-Picot, I. (1997). Oxidative Stress in Alzheimer’s Disease. In: The Role of Oxidative Stress in Neuronal Death. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22516-5_5

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  • DOI: https://doi.org/10.1007/978-3-662-22516-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22518-9

  • Online ISBN: 978-3-662-22516-5

  • eBook Packages: Springer Book Archive

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