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Sphingolipid-Mediated Signal Transduction pp 19–34Cite as

Ceramide: A Stress Response Mediator Involved in Growth Suppression

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Cell membranes are composed of a lipid bilayer comprised mostly of phospholipids. The majority of these lipids are glyceride-based and are termed gylcerolipids. Sphingolipids comprise less than 3% of cell membrane lipids and utilize ceramide as a backbone. This group of membrane lipids exhibits wide diversity, mostly due to the complexity of head groups at the carbon 1 (C1) position which exhibit both species and tissue specificity (Fig. 2.1). For a long time, much of the research on sphingolipids focused on the glycosphingolipids and the role of the glycosyl head group in biologic processes.1 A number of functions were associated with the glycosphingolipids, including a role in cellular interaction, differentiation, and oncogenic transformation.2 Additionally, complex glycosphingolipids were shown to serve as antigens important in the immune response, as receptors for viruses or bacteria, and as tumor markers.1,3

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  1. Ghassan Dbaibo
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  2. Yusuf A. Hannun
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© 1997 Springer-Verlag Berlin Heidelberg

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Dbaibo, G., Hannun, Y.A. (1997). Ceramide: A Stress Response Mediator Involved in Growth Suppression. In: Sphingolipid-Mediated Signal Transduction. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22425-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-22425-0_2

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