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Preclinical Studies of Preactivated Merocyanine 540 and Merodantoin

  • Kirpal S. Gulliya
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Part of the Medical Intelligence Unit book series (MIU.LANDES)

Abstract

It is apparent from the discussion in the previous chapters that photoproducts in pMC540 display a significant toxicity against cultured tumor cells and enveloped viruses but are only minimally cytotoxic to normal cells. A question of obvious significance is whether these findings from in vitro studies have any relevance to cancer or viral infections in humans. In this chapter, we shall examine the data obtained from studies utilizing in vivo models that support further development of these compounds for ultimate clinical use.

Keywords

Nude Mouse Breast Tumor Chemotherapeutic Agent Hypoxic Cell Athymic Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Kirpal S. Gulliya
    • 1
    • 2
    • 3
  1. 1.Baylor Research InstituteBaylor University Medical CenterDallasUSA
  2. 2.Institute of Biomedical StudiesBaylor UniversityWacoUSA
  3. 3.Department of Biological ScienceUniversity of North TexasDentonUSA

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