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Clinical Potential

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Neural Transplantation in Cerebellar Ataxia

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

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Abstract

Clinical trials with fetal mesencephalic grafts into the caudate nucleus or putamen have been reported in parkinsonian patients in medical centers of several countries, including Sweden,1–16 United Kingdom,17–28 Mexico,29,30 United States,31–47 Cuba,48 Russia,49 Czech Republic, 50 Slovakia,51 Canada,52 Spain,53,54 China,55 Poland56 and France.57 Such trials have been prompted by encouraging results from extensive experimental studies in rodent and primate models. Evidence for graft survival4,12,13,16,26,28,35,42,44,57 and functional improvement of clinical signs1–29,31–57 has been presented in many of those studies. Reported variations in the outcome of the procedure might relate inter alia to technique and site of grafting, age and method of preparation of donor tissue, stage of advancement of the disease in the host and pharmacological scheme of the patients prior to the operation.

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  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Lazaros C. Triarhou M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Triarhou, L.C. (1997). Clinical Potential. In: Neural Transplantation in Cerebellar Ataxia. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22213-3_9

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  • DOI: https://doi.org/10.1007/978-3-662-22213-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22215-7

  • Online ISBN: 978-3-662-22213-3

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