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Role of ATP-Sensitive Potassium Channels in Myocardial Preconditioning

  • Chapter
Myocardial Preconditioning

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

The past few years have seen an explosive growth of research on the mechanism of myocardial preconditioning. There has also recently been an increased interest in the role of ATP-sensitive potassium channels (KATP) in the pathogenesis of myocardial ischemia. These two originally distinct lines of investigation intersected with the publication by Gross and colleagues showing that preconditioning in dogs can be abolished by the KATP blocker glyburide (glibenclamide).1 In this chapter I will describe the sequence of studies which led to the KATP hypothesis for preconditioning and I will present these data in a manner which will inform the reader of the thought processes leading to our current understanding (whether right or wrong) of the role of KATP in mediating myocardial preconditioning. First, I will describe what is known about cardiac KATP. I will then review the data describing the pharmacology of the cardioprotective effects of KATP openers. This will be done to show that the pharmacological profile of cardioprotection by KATP openers is consistent in many respects to that observed for preconditioning (preconditioning mimetic). I will then describe the studies showing the effects of KATP blockers on preconditioning. It turns out that the order in which the data are presented in this chapter are also generally in chronological order, therefore giving the reader an historical perspective of the field.

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  1. Gary J. Grover
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© 1996 Springer-Verlag Berlin Heidelberg

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Grover, G.J. (1996). Role of ATP-Sensitive Potassium Channels in Myocardial Preconditioning. In: Myocardial Preconditioning. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22206-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-22206-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22208-9

  • Online ISBN: 978-3-662-22206-5

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