Abstract
For many years, the prevailing schema of alloreactivity made local immunosuppression illogical.1 The understanding was that a vascularized allograft was recognized by the host through peripheral sensitization. Host immune cells circulating through the graft were exposed to nonself histocompatibility antigens. Subsequent proliferation of responder cells occurred in the spleen or lymph nodes. The effector response was mediated by sensitized lymphoid cells returning to the graft and destroying cells bearing foreign histocompatibility antigens. Nonspecific immunosuppressive agents, such as azathioprine and steroids, interfered with proliferating cells in the spleen and other lymphoid depots. Given this schema, the value of immunosuppression at the graft site was doubtful.
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Dafoe, D.C., Alfrey, E.J. (1996). Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allografts. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_8
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DOI: https://doi.org/10.1007/978-3-662-22105-1_8
Publisher Name: Springer, Berlin, Heidelberg
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