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Selective Immunosuppression by Local Treatment of the Allograft

Studies on Intrarenal Prednisolone and Intracardiac Budesonide Delivery in the Rat

  • Chapter
Local Immunosuppression of Organ Transplants

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

So far immunosuppressive therapy after organ transplantation consists of systemic inhibition of the immune response. Recently however, controversy has increased concerning the role of systemic versus local regulatory mechanisms in the cellular immune response.1,2 Immune stimulation by major histocompatibility complex (MHC) antigen expression has been seen as a local as well as a systemic process in both allograft rejection and autoimmune disease.3–9 The same controversy holds true for the effector mechanisms during cellular immune responses.1,2,10–13 If however, local regulatory mechanisms within the graft are of major importance during the rejection response, the allograft would be a favorable subject for local immunosuppressive therapy. In this way, allograft survival could be induced by local immunosuppression within the graft, while systemic side effects of immunosuppressive therapy are avoided. We have investigated this approach by local drug delivery to rat renal and cardiac allografts and were able to demonstrate that local treatment of allograft rejection is indeed an effective approach to induce selective immunosuppression.

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Authors
  1. T. J. M. Ruers
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© 1996 Springer-Verlag Berlin Heidelberg

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Ruers, T.J.M. (1996). Selective Immunosuppression by Local Treatment of the Allograft. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_4

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  • DOI: https://doi.org/10.1007/978-3-662-22105-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22107-5

  • Online ISBN: 978-3-662-22105-1

  • eBook Packages: Springer Book Archive

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