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Interleukin-10 pp 59–67Cite as

IL-10 and Bone Formation/Hematopoiesis

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Considering the anatomical localization of bone and bone marrow it is not surprising that both tissues are composed of cells from hematopoietic as well as from stromal origin. Indeed, apart from the stroma-derived osteoblasts and osteocytes, which are characterized by their ability to produce a mineralized matrix1,2 bone also contains osteoclasts. Osteoclasts belong to the hematopoietic lineage and have a lot in common with macrophages and characteristically resorb bone.3,4 The hematopoietic compartment of the bone marrow on the other hand, is functionally and structurally supported by a microenvironment of stromal elements including adipocytes, fibroblasts, endothelial cells and undifferentiated mesenchymal cells. These mesenchymal cells represent a reservoir of “uncommitted”, self-renewing cells which differentiate into various stromal elements, including bone.2,5 Under normal conditions, hematopoiesis and stromal differentiation require complex sequences of cellular events that are modulated by site-specific and cell-specific signals capable of initializing and promoting the recruitment and proliferation of the appropriate cells at the right time. These signals are mediated by hormones, prostaglandins, growth factors and cytokines which either reside in the bone matrix or in the bone marrow. The goal of this chapter is to review the effects of interleukin-10 (IL-10) on bone formation and hematopoiesis. IL-10 was initially described as cytokine synthesis inhibiting factor (CSIF) based on its potential to block the synthesis of cytokines produced by type 2 helper T cells.6

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Authors
  1. Peter Van Vlasselaer
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© 1995 Springer-Verlag Berlin Heidelberg

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Van Vlasselaer, P. (1995). IL-10 and Bone Formation/Hematopoiesis. In: Interleukin-10. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22038-2_7

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  • DOI: https://doi.org/10.1007/978-3-662-22038-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22040-5

  • Online ISBN: 978-3-662-22038-2

  • eBook Packages: Springer Book Archive

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