Abstract
The original activity of interleukin-10 (IL-10), which led to its characterization at the molecular level was its ability to inhibit the induction of cytokine production by Thl clones1–3 and as a result of this it was given the name cytokine synthesis inhibitory factor (CSIF). IL-10, was first isolated from activated Th2-type, T helper cells, which produce cytokines promoting humoral and allergic type immune responses.4 Its ability to inhibit the production of cytokines such as IFN-γ from Thltype cells which mediate cell-mediated type immune responses, offered a possible explanation for why humoral and cell-mediated immune responses are often mutually exclusive.5
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O’Garra, A. (1995). Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells. In: Interleukin-10. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22038-2_6
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DOI: https://doi.org/10.1007/978-3-662-22038-2_6
Publisher Name: Springer, Berlin, Heidelberg
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